COMPOUNDS WITH MEDICINAL EFFECTS DUE TO INTERACTION WITH THE GLUCOCORTICOID RECEPTOR
The invention provides for compounds having the structure according to the formula I wherein: X is a carbon or nitrogen atom; Ar is phenyl or heteroaromatic ring; Ris hydrogen, halogen, CN or (1C-)alkyl; Ris hydrogen, halogen or optionally fluorinated (1C-)alkoxy; Rand Rare independently hydrogen, o...
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| creator | HO KOC-KAN HAMILTON NIALL MORTON KULTGEN STEVEN G KINGSBURY CELIA OHLMEYER MICHAEL LITTLEWOOD PETER THOMAS ALBERT KICZUN MICHAEL JOHN SHERBORNE BRAD MORPHY JOHN RICHARD BROWN ANGUS RICHARD GROVE SIMON JAMES ANTHONY |
| description | The invention provides for compounds having the structure according to the formula I wherein: X is a carbon or nitrogen atom; Ar is phenyl or heteroaromatic ring; Ris hydrogen, halogen, CN or (1C-)alkyl; Ris hydrogen, halogen or optionally fluorinated (1C-)alkoxy; Rand Rare independently hydrogen, optionally halogenated (1C-)alkyl, optionally halogenated (1 C-)alkoxy, optionally halogenated aryl(1C-)alkoxy, optionally halogenated (1C-)alkenyl or hydroxylmethyl; Ris hydrogen, halogen, optionally halogenated (1C-)alkoxy or optionally halogenated aryl(1C-)alkoxy; Ris hydrogen, benzyl, optionally substituted with one or more halogens or (1C-)alkyl, or Ris optionally halogenated (1C-)alkyl; each Rindependently is hydrogen, halogen, optionally halogenated (1C-)alkyl or optionally halogenated (1C-)alkoxy and pharmaceutically suitable acid addition salts thereof for use as glucocorticoid receptor modulators, in particular for treatment of central nervous system disorders., (I)
Изобретение касается соединения, которое имеет структуру формулы I, (I)или его фармацевтически приемлемой кислотно-аддитивной соли, а также применения указанного соединения как модулятора рецептора глюкокортикоида, в частности, для лечения расстройств центральной нервной системы.
Винахід стосується сполуки, що має структуру формули I, (I)або її фармацевтично прийнятної кислотно-адитивної солі, а також застосування зазначеної сполуки як модулятора рецептора глюкокортикоїду, зокрема, для лікування розладів центральної нервової системи. |
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Изобретение касается соединения, которое имеет структуру формулы I, (I)или его фармацевтически приемлемой кислотно-аддитивной соли, а также применения указанного соединения как модулятора рецептора глюкокортикоида, в частности, для лечения расстройств центральной нервной системы.
Винахід стосується сполуки, що має структуру формули I, (I)або її фармацевтично прийнятної кислотно-адитивної солі, а також застосування зазначеної сполуки як модулятора рецептора глюкокортикоїду, зокрема, для лікування розладів центральної нервової системи.</description><language>eng ; rus ; ukr</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2011</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110125&DB=EPODOC&CC=UA&NR=93217C2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110125&DB=EPODOC&CC=UA&NR=93217C2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HO KOC-KAN</creatorcontrib><creatorcontrib>HAMILTON NIALL MORTON</creatorcontrib><creatorcontrib>KULTGEN STEVEN G</creatorcontrib><creatorcontrib>KINGSBURY CELIA</creatorcontrib><creatorcontrib>OHLMEYER MICHAEL</creatorcontrib><creatorcontrib>LITTLEWOOD PETER THOMAS ALBERT</creatorcontrib><creatorcontrib>KICZUN MICHAEL JOHN</creatorcontrib><creatorcontrib>SHERBORNE BRAD</creatorcontrib><creatorcontrib>MORPHY JOHN RICHARD</creatorcontrib><creatorcontrib>BROWN ANGUS RICHARD</creatorcontrib><creatorcontrib>GROVE SIMON JAMES ANTHONY</creatorcontrib><title>COMPOUNDS WITH MEDICINAL EFFECTS DUE TO INTERACTION WITH THE GLUCOCORTICOID RECEPTOR</title><description>The invention provides for compounds having the structure according to the formula I wherein: X is a carbon or nitrogen atom; Ar is phenyl or heteroaromatic ring; Ris hydrogen, halogen, CN or (1C-)alkyl; Ris hydrogen, halogen or optionally fluorinated (1C-)alkoxy; Rand Rare independently hydrogen, optionally halogenated (1C-)alkyl, optionally halogenated (1 C-)alkoxy, optionally halogenated aryl(1C-)alkoxy, optionally halogenated (1C-)alkenyl or hydroxylmethyl; Ris hydrogen, halogen, optionally halogenated (1C-)alkoxy or optionally halogenated aryl(1C-)alkoxy; Ris hydrogen, benzyl, optionally substituted with one or more halogens or (1C-)alkyl, or Ris optionally halogenated (1C-)alkyl; each Rindependently is hydrogen, halogen, optionally halogenated (1C-)alkyl or optionally halogenated (1C-)alkoxy and pharmaceutically suitable acid addition salts thereof for use as glucocorticoid receptor modulators, in particular for treatment of central nervous system disorders., (I)
Изобретение касается соединения, которое имеет структуру формулы I, (I)или его фармацевтически приемлемой кислотно-аддитивной соли, а также применения указанного соединения как модулятора рецептора глюкокортикоида, в частности, для лечения расстройств центральной нервной системы.
Винахід стосується сполуки, що має структуру формули I, (I)або її фармацевтично прийнятної кислотно-адитивної солі, а також застосування зазначеної сполуки як модулятора рецептора глюкокортикоїду, зокрема, для лікування розладів центральної нервової системи.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2011</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFyrEKwjAQANAsDqL-gtwPONgO4hguF3PQ5kp6wbEUSaeihfr_OOju9Ja3NYrSdpKj6-HOGqAlx8jRNkDeE2oPLhOoAEelZFFZ4ndqILg1GQUlKaOwg0RInUram800zms5_NyZoyfFcCrLayjrMj7Ks7yHbK91db5gVf8NHy-DLyk</recordid><startdate>20110125</startdate><enddate>20110125</enddate><creator>HO KOC-KAN</creator><creator>HAMILTON NIALL MORTON</creator><creator>KULTGEN STEVEN G</creator><creator>KINGSBURY CELIA</creator><creator>OHLMEYER MICHAEL</creator><creator>LITTLEWOOD PETER THOMAS ALBERT</creator><creator>KICZUN MICHAEL JOHN</creator><creator>SHERBORNE BRAD</creator><creator>MORPHY JOHN RICHARD</creator><creator>BROWN ANGUS RICHARD</creator><creator>GROVE SIMON JAMES ANTHONY</creator><scope>EVB</scope></search><sort><creationdate>20110125</creationdate><title>COMPOUNDS WITH MEDICINAL EFFECTS DUE TO INTERACTION WITH THE GLUCOCORTICOID RECEPTOR</title><author>HO KOC-KAN ; HAMILTON NIALL MORTON ; KULTGEN STEVEN G ; KINGSBURY CELIA ; OHLMEYER MICHAEL ; LITTLEWOOD PETER THOMAS ALBERT ; KICZUN MICHAEL JOHN ; SHERBORNE BRAD ; MORPHY JOHN RICHARD ; BROWN ANGUS RICHARD ; GROVE SIMON JAMES ANTHONY</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_UA93217C23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; rus ; ukr</language><creationdate>2011</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>HO KOC-KAN</creatorcontrib><creatorcontrib>HAMILTON NIALL MORTON</creatorcontrib><creatorcontrib>KULTGEN STEVEN G</creatorcontrib><creatorcontrib>KINGSBURY CELIA</creatorcontrib><creatorcontrib>OHLMEYER MICHAEL</creatorcontrib><creatorcontrib>LITTLEWOOD PETER THOMAS ALBERT</creatorcontrib><creatorcontrib>KICZUN MICHAEL JOHN</creatorcontrib><creatorcontrib>SHERBORNE BRAD</creatorcontrib><creatorcontrib>MORPHY JOHN RICHARD</creatorcontrib><creatorcontrib>BROWN ANGUS RICHARD</creatorcontrib><creatorcontrib>GROVE SIMON JAMES ANTHONY</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HO KOC-KAN</au><au>HAMILTON NIALL MORTON</au><au>KULTGEN STEVEN G</au><au>KINGSBURY CELIA</au><au>OHLMEYER MICHAEL</au><au>LITTLEWOOD PETER THOMAS ALBERT</au><au>KICZUN MICHAEL JOHN</au><au>SHERBORNE BRAD</au><au>MORPHY JOHN RICHARD</au><au>BROWN ANGUS RICHARD</au><au>GROVE SIMON JAMES ANTHONY</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMPOUNDS WITH MEDICINAL EFFECTS DUE TO INTERACTION WITH THE GLUCOCORTICOID RECEPTOR</title><date>2011-01-25</date><risdate>2011</risdate><abstract>The invention provides for compounds having the structure according to the formula I wherein: X is a carbon or nitrogen atom; Ar is phenyl or heteroaromatic ring; Ris hydrogen, halogen, CN or (1C-)alkyl; Ris hydrogen, halogen or optionally fluorinated (1C-)alkoxy; Rand Rare independently hydrogen, optionally halogenated (1C-)alkyl, optionally halogenated (1 C-)alkoxy, optionally halogenated aryl(1C-)alkoxy, optionally halogenated (1C-)alkenyl or hydroxylmethyl; Ris hydrogen, halogen, optionally halogenated (1C-)alkoxy or optionally halogenated aryl(1C-)alkoxy; Ris hydrogen, benzyl, optionally substituted with one or more halogens or (1C-)alkyl, or Ris optionally halogenated (1C-)alkyl; each Rindependently is hydrogen, halogen, optionally halogenated (1C-)alkyl or optionally halogenated (1C-)alkoxy and pharmaceutically suitable acid addition salts thereof for use as glucocorticoid receptor modulators, in particular for treatment of central nervous system disorders., (I)
Изобретение касается соединения, которое имеет структуру формулы I, (I)или его фармацевтически приемлемой кислотно-аддитивной соли, а также применения указанного соединения как модулятора рецептора глюкокортикоида, в частности, для лечения расстройств центральной нервной системы.
Винахід стосується сполуки, що має структуру формули I, (I)або її фармацевтично прийнятної кислотно-адитивної солі, а також застосування зазначеної сполуки як модулятора рецептора глюкокортикоїду, зокрема, для лікування розладів центральної нервової системи.</abstract><oa>free_for_read</oa></addata></record> |
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| title | COMPOUNDS WITH MEDICINAL EFFECTS DUE TO INTERACTION WITH THE GLUCOCORTICOID RECEPTOR |
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