Purification of multispecific antibodies

The present invention provides methods of purifying multispecific antibodies. The methods comprise the sequential steps of performing a capture chromatography, a first mixed mode chromatography and a second mixed mode chromatography. In some aspects, the invention provides compositions of multispeci...

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Bibliographische Detailangaben
Hauptverfasser:	KALEAS, KIMBERLY, KONRAD, SUSANNE, WILLMANN, STEFFEN, KOEHNLEIN, WOLFGANG, YIGZAW, YINGES, GIESE, GLEN, ROSENBERG, EVA, BIALAS, AGATHE, SALLIER, BERNARD
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SEPARATION TRANSPORTING
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Beschreibung
Zusammenfassung:	The present invention provides methods of purifying multispecific antibodies. The methods comprise the sequential steps of performing a capture chromatography, a first mixed mode chromatography and a second mixed mode chromatography. In some aspects, the invention provides compositions of multispecific antibodies, which compositions have reduced levels of one or more product-specific impurities and/or process-specific impurities.