Pyrrolidinyl derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors

The N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n is 1 or 2; L represents a C1-3alkyl linker optionally substituted with one or two substituents selected from C1-4alkyl, C1-3alkyloxy-C1-4alkyl-, hydroxy-C1-4alkyl, hydroxy, C1...

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Hauptverfasser: JAROSKOVA, LIBUSE, LINDERS, JOANNES THEODORUS MARIA, BUYCK, CHRISTOPHE FRANCIS ROBERT NESTOR, VAN DER VEKEN, LOUIS JOZEF ELISABETH, DIMITROV, VLADIMIR DIMTCHEV, NIKIFOROV, THEO TEOFANOV
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creator JAROSKOVA, LIBUSE
LINDERS, JOANNES THEODORUS MARIA
BUYCK, CHRISTOPHE FRANCIS ROBERT NESTOR
VAN DER VEKEN, LOUIS JOZEF ELISABETH
DIMITROV, VLADIMIR DIMTCHEV
NIKIFOROV, THEO TEOFANOV
description The N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n is 1 or 2; L represents a C1-3alkyl linker optionally substituted with one or two substituents selected from C1-4alkyl, C1-3alkyloxy-C1-4alkyl-, hydroxy-C1-4alkyl, hydroxy, C1-3alkyloxy- or phenyl-C1-4alkyl; M represents a direct bond or a C1-3alkyl linker optionally substituted with one or two substituents selected from hydroxy, C1-4alkyl or C1-4alkyloxy; R1 and R2 each independently represent hydrogen, halo, cyano, hydroxy, C1-4alkyl optionally substituted with halo, C1-4alkyloxy- optionally substituted with one or where possible two or three substituents selected from hydroxy, Ar1 and halo; or R1 and R2 taken together with the phenyl ring to which they are attached form naphtyl or 1,3-benzodioxolyl, wherein said naphtyl or 1,3-benzodioxolyl are optionally substituted with halo; R3 represents hydrogen, halo, C1-4alkyl, C1-4alkyloxy-, cyano or hydroxy; R4 represents hydrogen, halo, C1-
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Pyrrolidinyl derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
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