Preparation of 3-isopropyl-1H-2,1,3-benzothiadiazin-4(3H)-one-2,2-dioxide

Preparation of 3-isopropyl-1H-2,1,3-benzothiadiazin-4(3H)-one-2,2-dioxide

A process for preparing 3-isopropy1-1H-2,1,3-benzothiadiazin-4(3H)-one-2,2-dioxide (I) or a salt of I, which comprises reacting anthranilic isopropylamide II, simultaneously with sulfur trioxide or chlorosulfonic acid in the presence of an organic base or with adducts of sulfur trioxide and organic...

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Bibliographische Detailangaben
Hauptverfasser: MULLER, ALBRECHT, FRETSCHNER, ERICH, WOERZ, OTTO, MERKLE, HANS RUPERT, HANSEN, HANSPETER
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:A process for preparing 3-isopropy1-1H-2,1,3-benzothiadiazin-4(3H)-one-2,2-dioxide (I) or a salt of I, which comprises reacting anthranilic isopropylamide II, simultaneously with sulfur trioxide or chlorosulfonic acid in the presence of an organic base or with adducts of sulfur trioxide and organic bases and phosphorus oxychloride at from 50 DEG C to the reflux temperature, followed, if appropriate, by conversion into its salts, is described.