Process for the preparation of a gadolinium contrast agent

The present invention relates to a process for the preparation of a gadolinium chelate compound of formula (I) or its stereoisomers, tautomers, N-oxides, hydrates, solvates, or salts thereof, or mixtures of same. Further, the present invention relates to crystalline forms of the gadolinium chelate o...

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Hauptverfasser: BOEDDINGHAUS, NICOLE, KUNELLIS, JANRISTIAN, BALZER, SANDRA, HOG, DANIEL, SCHIRMER, HEIKO, GRUBE, STEFAN, EBHARDT, LASSE, TERWILLIGER, DANIEL WILLIAM, LONGERICH, MARKUS, JACOBS, TIA, PLATZEK, JOHANNES, ULFERTS-HANEL, ANITA
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creator BOEDDINGHAUS, NICOLE
KUNELLIS, JANRISTIAN
BALZER, SANDRA
HOG, DANIEL
SCHIRMER, HEIKO
GRUBE, STEFAN
EBHARDT, LASSE
TERWILLIGER, DANIEL WILLIAM
LONGERICH, MARKUS
JACOBS, TIA
PLATZEK, JOHANNES
ULFERTS-HANEL, ANITA
description The present invention relates to a process for the preparation of a gadolinium chelate compound of formula (I) or its stereoisomers, tautomers, N-oxides, hydrates, solvates, or salts thereof, or mixtures of same. Further, the present invention relates to crystalline forms of the gadolinium chelate of formula (I), to a process for the preparation of said crystalline forms as well as to intermediate compounds in the synthesis of the gadolinium chelate compound of formula (I) and/or its crystalline forms as well as their stereoisomers, tautomers, N-oxides, hydrates, solvates, or salts thereof, or mixtures of same.
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subjects ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title Process for the preparation of a gadolinium contrast agent
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