Systems and methods to identify MHC-associated antigens for therapeutic intervention

The present disclosure relates to compositions and methods of uses of a monoallelic MHC-expressing cell line, as well as method of identifying a neoepitope-MHC binding pair and methods of treating a subject having a cancer or tumor expressing a neoantigen and a MHC allele.

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Bibliographische Detailangaben
Hauptverfasser:	DARWISH, MARTINE ABRAHAM, LI, JUAN, ROSE, CHRISTOPHER MICHAEL, HALEY, BENJAMIN JOSEPH, CHAN, PAMELA PUI FUNG, HEIDERSBACH, AMY JEANE, BLANCHETTE, CRAIG, GURUNG, HEM RAJ, TONG, ANN-JAY
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
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Beschreibung
Zusammenfassung:	The present disclosure relates to compositions and methods of uses of a monoallelic MHC-expressing cell line, as well as method of identifying a neoepitope-MHC binding pair and methods of treating a subject having a cancer or tumor expressing a neoantigen and a MHC allele.