Methods for predicting and modulating glycation of a protein

Embodiments provide for methods of predicting glycation percentage of an amino acid in a therapeutic biomolecule. In one example, a method of predicting a glycation percentage of an amino acid in a biomolecule includes determining a first set of rates for a de-glycation reaction for a first set of t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	GRAHAM, KENNETH, KAMEN, DOUGLAS, XU, XIAO-BIN, QIU, HAIBO, YANG, TENGIEH
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS TESTING
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page
container_issue
container_start_page
container_title
container_volume
creator	GRAHAM, KENNETH KAMEN, DOUGLAS XU, XIAO-BIN QIU, HAIBO YANG, TENGIEH
description	Embodiments provide for methods of predicting glycation percentage of an amino acid in a therapeutic biomolecule. In one example, a method of predicting a glycation percentage of an amino acid in a biomolecule includes determining a first set of rates for a de-glycation reaction for a first set of temperatures, inferring a second set of one or more rate(s) for the de-glycation reaction for a second set of temperatures, and using the second set of one or more rate(s) to predict the glycation percentage at any temperature corresponding to the second set of temperatures and over any time duration. Also provided are methods for maintaining a glycation percentage of an amino acid within a predetermined glycation percentage range over a shelf-life of a therapeutic biomolecule, and methods for either reducing or increasing a potency of a therapeutic biomolecule in a subject at a time of administration.
format	Patent
fullrecord	<record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_TW202305368A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>TW202305368A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_TW202305368A3</originalsourceid><addsrcrecordid>eNrjZLDxTS3JyE8pVkjLL1IoKEpNyUwuycxLV0jMS1HIzU8pzUkEc9NzKpOBrPw8hfw0hUSgwvyS1Mw8HgbWtMSc4lReKM3NoOjmGuLsoZtakB-fWlyQmJyal1oSHxJuZGBkbGBqbGbhaEyMGgDwwi_9</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Methods for predicting and modulating glycation of a protein</title><source>esp@cenet</source><creator>GRAHAM, KENNETH ; KAMEN, DOUGLAS ; XU, XIAO-BIN ; QIU, HAIBO ; YANG, TENGIEH</creator><creatorcontrib>GRAHAM, KENNETH ; KAMEN, DOUGLAS ; XU, XIAO-BIN ; QIU, HAIBO ; YANG, TENGIEH</creatorcontrib><description>Embodiments provide for methods of predicting glycation percentage of an amino acid in a therapeutic biomolecule. In one example, a method of predicting a glycation percentage of an amino acid in a biomolecule includes determining a first set of rates for a de-glycation reaction for a first set of temperatures, inferring a second set of one or more rate(s) for the de-glycation reaction for a second set of temperatures, and using the second set of one or more rate(s) to predict the glycation percentage at any temperature corresponding to the second set of temperatures and over any time duration. Also provided are methods for maintaining a glycation percentage of an amino acid within a predetermined glycation percentage range over a shelf-life of a therapeutic biomolecule, and methods for either reducing or increasing a potency of a therapeutic biomolecule in a subject at a time of administration.</description><language>chi ; eng</language><subject>CHEMISTRY ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; TESTING</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230201&DB=EPODOC&CC=TW&NR=202305368A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230201&DB=EPODOC&CC=TW&NR=202305368A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GRAHAM, KENNETH</creatorcontrib><creatorcontrib>KAMEN, DOUGLAS</creatorcontrib><creatorcontrib>XU, XIAO-BIN</creatorcontrib><creatorcontrib>QIU, HAIBO</creatorcontrib><creatorcontrib>YANG, TENGIEH</creatorcontrib><title>Methods for predicting and modulating glycation of a protein</title><description>Embodiments provide for methods of predicting glycation percentage of an amino acid in a therapeutic biomolecule. In one example, a method of predicting a glycation percentage of an amino acid in a biomolecule includes determining a first set of rates for a de-glycation reaction for a first set of temperatures, inferring a second set of one or more rate(s) for the de-glycation reaction for a second set of temperatures, and using the second set of one or more rate(s) to predict the glycation percentage at any temperature corresponding to the second set of temperatures and over any time duration. Also provided are methods for maintaining a glycation percentage of an amino acid within a predetermined glycation percentage range over a shelf-life of a therapeutic biomolecule, and methods for either reducing or increasing a potency of a therapeutic biomolecule in a subject at a time of administration.</description><subject>CHEMISTRY</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>TESTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLDxTS3JyE8pVkjLL1IoKEpNyUwuycxLV0jMS1HIzU8pzUkEc9NzKpOBrPw8hfw0hUSgwvyS1Mw8HgbWtMSc4lReKM3NoOjmGuLsoZtakB-fWlyQmJyal1oSHxJuZGBkbGBqbGbhaEyMGgDwwi_9</recordid><startdate>20230201</startdate><enddate>20230201</enddate><creator>GRAHAM, KENNETH</creator><creator>KAMEN, DOUGLAS</creator><creator>XU, XIAO-BIN</creator><creator>QIU, HAIBO</creator><creator>YANG, TENGIEH</creator><scope>EVB</scope></search><sort><creationdate>20230201</creationdate><title>Methods for predicting and modulating glycation of a protein</title><author>GRAHAM, KENNETH ; KAMEN, DOUGLAS ; XU, XIAO-BIN ; QIU, HAIBO ; YANG, TENGIEH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_TW202305368A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>TESTING</topic><toplevel>online_resources</toplevel><creatorcontrib>GRAHAM, KENNETH</creatorcontrib><creatorcontrib>KAMEN, DOUGLAS</creatorcontrib><creatorcontrib>XU, XIAO-BIN</creatorcontrib><creatorcontrib>QIU, HAIBO</creatorcontrib><creatorcontrib>YANG, TENGIEH</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GRAHAM, KENNETH</au><au>KAMEN, DOUGLAS</au><au>XU, XIAO-BIN</au><au>QIU, HAIBO</au><au>YANG, TENGIEH</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Methods for predicting and modulating glycation of a protein</title><date>2023-02-01</date><risdate>2023</risdate><abstract>Embodiments provide for methods of predicting glycation percentage of an amino acid in a therapeutic biomolecule. In one example, a method of predicting a glycation percentage of an amino acid in a biomolecule includes determining a first set of rates for a de-glycation reaction for a first set of temperatures, inferring a second set of one or more rate(s) for the de-glycation reaction for a second set of temperatures, and using the second set of one or more rate(s) to predict the glycation percentage at any temperature corresponding to the second set of temperatures and over any time duration. Also provided are methods for maintaining a glycation percentage of an amino acid within a predetermined glycation percentage range over a shelf-life of a therapeutic biomolecule, and methods for either reducing or increasing a potency of a therapeutic biomolecule in a subject at a time of administration.</abstract><oa>free_for_read</oa></addata></record>
fulltext	fulltext_linktorsrc
identifier
ispartof
issn
language	chi ; eng
recordid	cdi_epo_espacenet_TW202305368A
source	esp@cenet
subjects	CHEMISTRY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS TESTING
title	Methods for predicting and modulating glycation of a protein
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T23%3A38%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=GRAHAM,%20KENNETH&rft.date=2023-02-01&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ETW202305368A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true