Heterocyclic compounds as kinase inhibitor and uses thereof
The present disclosure relates generally to compounds useful in treatment of conditions associated with Checkpoint kinase (CHK), particularly CHK-1 enzymes. Specifically, the present invention discloses compound of formula (J), which exhibits inhibitory activity against CHK-1 enzymes. Methods of tre...
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| creator | YAN, ZHI-YU LIU, HANLAN PUJALA, BRAHMAM JADHAVAR, PRADEEP S PANPATIL, DAYANAND WANG, XIAO-HUI PENDHARKAR, DHANANJAY SAEED, UZMA KUMAR, VIVEK KHAN, PASHA M |
| description | The present disclosure relates generally to compounds useful in treatment of conditions associated with Checkpoint kinase (CHK), particularly CHK-1 enzymes. Specifically, the present invention discloses compound of formula (J), which exhibits inhibitory activity against CHK-1 enzymes. Methods of treating conditions associated with excessive activity of CHK-1 enzymes such as cancer, idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH) with such compounds is disclosed. Uses thereof, pharmaceutical compositions, kits and method of synthesis also disclosed. |
| format | Patent |
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Specifically, the present invention discloses compound of formula (J), which exhibits inhibitory activity against CHK-1 enzymes. Methods of treating conditions associated with excessive activity of CHK-1 enzymes such as cancer, idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH) with such compounds is disclosed. 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| title | Heterocyclic compounds as kinase inhibitor and uses thereof |
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