KRAS specific antibodies and uses thereof
Provided herein are anti-KRas antibodies that bind to mutant KRas-GDP and alkylated mutant KRas-GDP and methods of using the same. Also provide herein are method of screening for KRas inhibitors and methods of measuring binding of KRas to the antibodies described herein.
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | chi ; eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | MULVIHILL, MELINDA M WANG, WEIRU QUINN, JOHN GERARD KOERBER, JAMES THOMAS STEFFEK, MICAH EVANGELISTA, MARIE BRUNING, JOHN DAVIES, CHRISTOPHER WILLIAMSON |
| description | Provided herein are anti-KRas antibodies that bind to mutant KRas-GDP and alkylated mutant KRas-GDP and methods of using the same. Also provide herein are method of screening for KRas inhibitors and methods of measuring binding of KRas to the antibodies described herein. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_TW202204420A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>TW202204420A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_TW202204420A3</originalsourceid><addsrcrecordid>eNrjZND0DnIMViguSE3OTMtMVkjMK8lMyk_JTC0GMlMUSouBjJKM1KLU_DQeBta0xJziVF4ozc2g6OYa4uyhm1qQH59aXJCYnJqXWhIfEm5kYGRkYGJiZOBoTIwaAMTgKD0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>KRAS specific antibodies and uses thereof</title><source>esp@cenet</source><creator>MULVIHILL, MELINDA M ; WANG, WEIRU ; QUINN, JOHN GERARD ; KOERBER, JAMES THOMAS ; STEFFEK, MICAH ; EVANGELISTA, MARIE ; BRUNING, JOHN ; DAVIES, CHRISTOPHER WILLIAMSON</creator><creatorcontrib>MULVIHILL, MELINDA M ; WANG, WEIRU ; QUINN, JOHN GERARD ; KOERBER, JAMES THOMAS ; STEFFEK, MICAH ; EVANGELISTA, MARIE ; BRUNING, JOHN ; DAVIES, CHRISTOPHER WILLIAMSON</creatorcontrib><description>Provided herein are anti-KRas antibodies that bind to mutant KRas-GDP and alkylated mutant KRas-GDP and methods of using the same. Also provide herein are method of screening for KRas inhibitors and methods of measuring binding of KRas to the antibodies described herein.</description><language>chi ; eng</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; TESTING</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220201&DB=EPODOC&CC=TW&NR=202204420A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220201&DB=EPODOC&CC=TW&NR=202204420A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MULVIHILL, MELINDA M</creatorcontrib><creatorcontrib>WANG, WEIRU</creatorcontrib><creatorcontrib>QUINN, JOHN GERARD</creatorcontrib><creatorcontrib>KOERBER, JAMES THOMAS</creatorcontrib><creatorcontrib>STEFFEK, MICAH</creatorcontrib><creatorcontrib>EVANGELISTA, MARIE</creatorcontrib><creatorcontrib>BRUNING, JOHN</creatorcontrib><creatorcontrib>DAVIES, CHRISTOPHER WILLIAMSON</creatorcontrib><title>KRAS specific antibodies and uses thereof</title><description>Provided herein are anti-KRas antibodies that bind to mutant KRas-GDP and alkylated mutant KRas-GDP and methods of using the same. Also provide herein are method of screening for KRas inhibitors and methods of measuring binding of KRas to the antibodies described herein.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>TESTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZND0DnIMViguSE3OTMtMVkjMK8lMyk_JTC0GMlMUSouBjJKM1KLU_DQeBta0xJziVF4ozc2g6OYa4uyhm1qQH59aXJCYnJqXWhIfEm5kYGRkYGJiZOBoTIwaAMTgKD0</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>MULVIHILL, MELINDA M</creator><creator>WANG, WEIRU</creator><creator>QUINN, JOHN GERARD</creator><creator>KOERBER, JAMES THOMAS</creator><creator>STEFFEK, MICAH</creator><creator>EVANGELISTA, MARIE</creator><creator>BRUNING, JOHN</creator><creator>DAVIES, CHRISTOPHER WILLIAMSON</creator><scope>EVB</scope></search><sort><creationdate>20220201</creationdate><title>KRAS specific antibodies and uses thereof</title><author>MULVIHILL, MELINDA M ; WANG, WEIRU ; QUINN, JOHN GERARD ; KOERBER, JAMES THOMAS ; STEFFEK, MICAH ; EVANGELISTA, MARIE ; BRUNING, JOHN ; DAVIES, CHRISTOPHER WILLIAMSON</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_TW202204420A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2022</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>TESTING</topic><toplevel>online_resources</toplevel><creatorcontrib>MULVIHILL, MELINDA M</creatorcontrib><creatorcontrib>WANG, WEIRU</creatorcontrib><creatorcontrib>QUINN, JOHN GERARD</creatorcontrib><creatorcontrib>KOERBER, JAMES THOMAS</creatorcontrib><creatorcontrib>STEFFEK, MICAH</creatorcontrib><creatorcontrib>EVANGELISTA, MARIE</creatorcontrib><creatorcontrib>BRUNING, JOHN</creatorcontrib><creatorcontrib>DAVIES, CHRISTOPHER WILLIAMSON</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MULVIHILL, MELINDA M</au><au>WANG, WEIRU</au><au>QUINN, JOHN GERARD</au><au>KOERBER, JAMES THOMAS</au><au>STEFFEK, MICAH</au><au>EVANGELISTA, MARIE</au><au>BRUNING, JOHN</au><au>DAVIES, CHRISTOPHER WILLIAMSON</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>KRAS specific antibodies and uses thereof</title><date>2022-02-01</date><risdate>2022</risdate><abstract>Provided herein are anti-KRas antibodies that bind to mutant KRas-GDP and alkylated mutant KRas-GDP and methods of using the same. Also provide herein are method of screening for KRas inhibitors and methods of measuring binding of KRas to the antibodies described herein.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | chi ; eng |
| recordid | cdi_epo_espacenet_TW202204420A |
| source | esp@cenet |
| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING |
| title | KRAS specific antibodies and uses thereof |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T17%3A20%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=MULVIHILL,%20MELINDA%20M&rft.date=2022-02-01&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ETW202204420A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |