Method to isolate TCR genes

The present disclosure provides methods to recover repertoires of T cell receptors (TCRs). In some embodiments, TCR repertoires are recovered from non-viable samples. In some embodiments, libraries of TCR[alpha][beta] pairs are created. In some embodiments, the methods disclosed are used for cancer...

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Hauptverfasser:	LINNEMANN, CARSTEN, BENDLE, GAVIN M, GADIOT, JULES F.C, SCHRIKKEMA, DEBORAH SOPHIE, VAN HEIJST, JEROEN W.J, GOMEZ-EERLAND, RAQUEL, SCHUMACHER, ANTONIUS NICOLAAS MARIA, KUILMAN, THOMAS
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMBINATORIAL CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure provides methods to recover repertoires of T cell receptors (TCRs). In some embodiments, TCR repertoires are recovered from non-viable samples. In some embodiments, libraries of TCR[alpha][beta] pairs are created. In some embodiments, the methods disclosed are used for cancer immunotherapy or diagnostic purposes.