Acyl sulfonamides for treating cancer
The present invention provides acyl sulfonamide compounds of general formula(I): in which X, R1, R2, R3, R4, R5, R6, Ra and Rb are as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combina...
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| creator | GRADL, STEFAN NIKOLAUS FERNANDEZ-MONTALVAN, AMAURY ERNESTO NEUHAUS, ROLAND KORR, DANIEL PUTTER, VERA GORJANACZ, MATYAS FERRARA, STEVEN JAMES JAFFE, JACOB D TER LAAK, ANTONIUS HILLIG, ROMAN BOUCHE, LEA AURELIE BARAK, NAOMI STRATHDEE, CRAIG HERBERT, SIMON ANTHONY |
| description | The present invention provides acyl sulfonamide compounds of general formula(I): in which X, R1, R2, R3, R4, R5, R6, Ra and Rb are as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients as well as methods of treating and/or prophylaxing diseases, particularly cancer, more particularly cancer in which KAT6A and/or KAT6B is focally amplified, said method comprising administering an effective amount of at least one compound of formula (I) to a subject in need thereof. |
| format | Patent |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Acyl sulfonamides for treating cancer |
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