5-azaindazole derivatives as adenosine receptor antagonists

The present invention relates to novel 5-azaindazole derivatives of formula (I), as described and defined herein, and pharmaceutically acceptable salts, solvates and prodrug thereof, as well as pharmaceutical compositions comprising such compounds. The 5-azaindazole derivatives according to the inve...

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Hauptverfasser: MAYER, STANISLAS, FER, MICKAEL, AMALRIC, CAMILLE, MANTEAU, BAPTISTE, SCHANN, STEPHAN, BLAYO, ANNE-LAURE
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creator MAYER, STANISLAS
FER, MICKAEL
AMALRIC, CAMILLE
MANTEAU, BAPTISTE
SCHANN, STEPHAN
BLAYO, ANNE-LAURE
description The present invention relates to novel 5-azaindazole derivatives of formula (I), as described and defined herein, and pharmaceutically acceptable salts, solvates and prodrug thereof, as well as pharmaceutical compositions comprising such compounds. The 5-azaindazole derivatives according to the invention have been found to be highly effective dual A2A/A2B adenosine receptor antagonists, and can thus be used as therapeutic agents, particularly in the treatment or prevention of hyperproliferative or infectious diseases or disorders.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title 5-azaindazole derivatives as adenosine receptor antagonists
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