Lactulose glycoside compound, preparation method thereof and medicinal use thereof for providing the function of colon-localized drug release to prevent or treat the intestinal diseases

The present invention relates to the field of medicinal chemistry and, in particular, to a compound represented by formula (I), a preparation method thereof, and a medicinal use thereof. In the compound represented by the formula (I), the lactulose group is connected to a heteroatom in aglycon (G) through a glycoside bond. The aglycon (G) is a group formed by removing a hydrogen atom from a heteroatom of an active drug molecule and, as represented by the zigzag-like symbol, the lactulose group is connected to a heteroatom in the aglycon (G) through an -glycoside bond or a -glycoside bond. The pharmacokinetic test proves that the lactulose glycoside compound according to the present invention may pass through the mammalian gastrointestinal tract without being significantly absorbed by the gastrointestinal tract and without being significantly hydrolyzed by endogenous enzymes of the mammalian host, so that the lactulose glycoside compound may reach the mammalian colon portion to release the active drug in the c