Novel pyrimidine derivatives

The invention concerns compounds of Formula I, or a pharmaceutically acceptable salt thereof. where R1, n, R2, R3, and R4 are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their us...

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Bibliographische Detailangaben
Hauptverfasser:	DUCRAY, RICHARD, CROSS, DARREN ANTHONY EDWARD, PURKISS, STUART CHARLES, ASHTON, SUSAN ELIZABETH, EAST, SIMON JOHN, BARLAAM, BERNARD CHRISTOPHE, PEARSON, MARK ANDREW, KETTLE, JASON GRANT, WEDGE, STEPHEN ROBERT
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention concerns compounds of Formula I, or a pharmaceutically acceptable salt thereof. where R1, n, R2, R3, and R4 are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions which are sensitive to the inhibition of EphB4 kinases.