Solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler

Bu bulus, formül (I)e sahip bilesiklerin, virütik enfeksiyonlari, özellikle RSV enfeksiyonlarini tedavi etmeye mahsus bir ilaç üretiminde kullanimi ile ilgili olup; burada -a1=a2-a3=a4, -CH=CH-CH=CH-, -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH- veya -CH=CH-CH=N- formüle sahip bir radikaldir ve buradaki her bir hidrojen atomu, istege bagli olarak subsititüe edilebilir;Q,(b-1), (b-2), (b-3), (b-4), (b-5), (b-6), (b-7) ve (b-8) formülüne sahip bir radikaldir, G,bir dogrudan bag veya C1-10 alkandiildir;R1, istege bagli olarak sübstitüe edilmis bir monosiklik bir heterohalkadir.Formül (I)e sahip bazi bilesikler yenidir. This invention concerns compounds of formula prodrugs, N-oxides, addition salts, quaternary amines, metal complexes or stereochemically isomeric forms thereof wherein -a =a -a =a - is a radical of formula - CH=CH-CH=CH-, -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH-, -CH=CH-CH=N- wherein each hydrogen atom may optionally be substituted; Q is a radical of formula wherein Alk is C1-6alkanediyl; Y is a bivalent radical of formula -NR - or -CH(NR R )-; X is NR , S, S(=O), S(=O)2, O, CH2, C(=O), CH(=CH2), CH(OH), CH(CH3), CH(OCH3), CH(SCH3), CH(NR R ), CH2-NR or NR -CH2; X is a direct bond, CH2, C(=O), NR , C1-4alkyl-NR , NR -C1-4alkyl; t is 2 to 5; u is 1 to 5; v is 2 or 3; and whereby each hydrogen in Alk and in (b-3), (b-4), (b-5), (b-6), (b-7) and (b-8), may optionally be replaced by R ; provided that when R is hydroxy or C1-6alkyloxy, then R can not replace a hydrogen atom in the alpha position relative to a nitrogen atom; G is a direct bond or C1-10alkanediyl; R is an optionally substituted monocyclic heterocycle; R is hydrogen, formyl, pyrrolidinyl, piperidinyl, homoiperidinyl, C3- 7cycloalkyl or C1-10alkyl substituted with N(R )2 and optionally with another substituent; R is hydrogen, hydroxy, C1-6alkyl, C1-6alkyloxy, arylC1-6alkyl or arylC1- 6alkyloxy; R is hydrogen, C1-6alkyl or arylC1-6alkyl; R , R , R and R each independently are hydrogen or C1-6alkyl; or R and R , or R and R taken together from a bivalent radical of formula -(CH2)s- wherein s is 4 or 5; R is hydrogen, C1- 4alkyl, formyl, hydroxyC1-6alkyl, C1-6alkylcarbonyl or C1-alkyloxyarbonyl; aryl is optionally substituted phenyl; and their use for the manufacture of a medicament for the treatment of viral infections, in particular RSV infections.