METHOD OF PREPARING 1,4-DIHYDROPYRIDINECARBOXYLIC ACID ARALALKYL ESTERS
1,4-Dihydropyridines characterized by a carbo(arylalkoxy) group in the 5-position, an aryl group in the 4-position and a alkanoyl or carbalkoxy group in the 3-position and further optionally substituted in the 1,2 and 6-positions are coronary dilating, spasmolytic and hypotensive agents. The compoun...
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| creator | FRIDRIKH BOSSERT,DT STANISLAV KATSDA,DT EGBERT VEKHINGER,DT KURT SHTEPEL,DT VULF FATER,DT |
| description | 1,4-Dihydropyridines characterized by a carbo(arylalkoxy) group in the 5-position, an aryl group in the 4-position and a alkanoyl or carbalkoxy group in the 3-position and further optionally substituted in the 1,2 and 6-positions are coronary dilating, spasmolytic and hypotensive agents. The compounds, of which 2,6-dimethyl-3-carbomethoxy-4-(2-nitrophenyl)-5-carbobenzoxy-1,4-dihyd ropyridine is a representative embodiment, are prepared through the reaction of an ylidene- beta -dicarbonyl compound, which may be generated in situ from the corresponding beta -dicarbonyl compound and an aldehyde, and an enaminocarboxylic acid ester, which may also be generated in situ from a beta -dicarbonyl compound and an amine. |
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The compounds, of which 2,6-dimethyl-3-carbomethoxy-4-(2-nitrophenyl)-5-carbobenzoxy-1,4-dihyd ropyridine is a representative embodiment, are prepared through the reaction of an ylidene- beta -dicarbonyl compound, which may be generated in situ from the corresponding beta -dicarbonyl compound and an aldehyde, and an enaminocarboxylic acid ester, which may also be generated in situ from a beta -dicarbonyl compound and an amine.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1977</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19770925&DB=EPODOC&CC=SU&NR=574150A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19770925&DB=EPODOC&CC=SU&NR=574150A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>FRIDRIKH BOSSERT,DT</creatorcontrib><creatorcontrib>STANISLAV KATSDA,DT</creatorcontrib><creatorcontrib>EGBERT VEKHINGER,DT</creatorcontrib><creatorcontrib>KURT SHTEPEL,DT</creatorcontrib><creatorcontrib>VULF FATER,DT</creatorcontrib><title>METHOD OF PREPARING 1,4-DIHYDROPYRIDINECARBOXYLIC ACID ARALALKYL ESTERS</title><description>1,4-Dihydropyridines characterized by a carbo(arylalkoxy) group in the 5-position, an aryl group in the 4-position and a alkanoyl or carbalkoxy group in the 3-position and further optionally substituted in the 1,2 and 6-positions are coronary dilating, spasmolytic and hypotensive agents. The compounds, of which 2,6-dimethyl-3-carbomethoxy-4-(2-nitrophenyl)-5-carbobenzoxy-1,4-dihyd ropyridine is a representative embodiment, are prepared through the reaction of an ylidene- beta -dicarbonyl compound, which may be generated in situ from the corresponding beta -dicarbonyl compound and an aldehyde, and an enaminocarboxylic acid ester, which may also be generated in situ from a beta -dicarbonyl compound and an amine.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1977</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHD3dQ3x8HdR8HdTCAhyDXAM8vRzVzDUMdF18fSIdAnyD4gM8nTx9HN1dgxy8o-I9PF0VnB09nRRcAxy9HH08Y70UXANDnENCuZhYE1LzClO5YXS3Azybq4hzh66qQX58anFBYnJqXmpJfHBoabmJoamBo7GxoRVAAAufyvx</recordid><startdate>19770925</startdate><enddate>19770925</enddate><creator>FRIDRIKH BOSSERT,DT</creator><creator>STANISLAV KATSDA,DT</creator><creator>EGBERT VEKHINGER,DT</creator><creator>KURT SHTEPEL,DT</creator><creator>VULF FATER,DT</creator><scope>EVB</scope></search><sort><creationdate>19770925</creationdate><title>METHOD OF PREPARING 1,4-DIHYDROPYRIDINECARBOXYLIC ACID ARALALKYL ESTERS</title><author>FRIDRIKH BOSSERT,DT ; STANISLAV KATSDA,DT ; EGBERT VEKHINGER,DT ; KURT SHTEPEL,DT ; VULF FATER,DT</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_SU574150A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1977</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>FRIDRIKH BOSSERT,DT</creatorcontrib><creatorcontrib>STANISLAV KATSDA,DT</creatorcontrib><creatorcontrib>EGBERT VEKHINGER,DT</creatorcontrib><creatorcontrib>KURT SHTEPEL,DT</creatorcontrib><creatorcontrib>VULF FATER,DT</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>FRIDRIKH BOSSERT,DT</au><au>STANISLAV KATSDA,DT</au><au>EGBERT VEKHINGER,DT</au><au>KURT SHTEPEL,DT</au><au>VULF FATER,DT</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHOD OF PREPARING 1,4-DIHYDROPYRIDINECARBOXYLIC ACID ARALALKYL ESTERS</title><date>1977-09-25</date><risdate>1977</risdate><abstract>1,4-Dihydropyridines characterized by a carbo(arylalkoxy) group in the 5-position, an aryl group in the 4-position and a alkanoyl or carbalkoxy group in the 3-position and further optionally substituted in the 1,2 and 6-positions are coronary dilating, spasmolytic and hypotensive agents. The compounds, of which 2,6-dimethyl-3-carbomethoxy-4-(2-nitrophenyl)-5-carbobenzoxy-1,4-dihyd ropyridine is a representative embodiment, are prepared through the reaction of an ylidene- beta -dicarbonyl compound, which may be generated in situ from the corresponding beta -dicarbonyl compound and an aldehyde, and an enaminocarboxylic acid ester, which may also be generated in situ from a beta -dicarbonyl compound and an amine.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | METHOD OF PREPARING 1,4-DIHYDROPYRIDINECARBOXYLIC ACID ARALALKYL ESTERS |
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