METHOD OF OBTAINING DERIVATIVES OF PHENEM OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS

There are provided compounds of formula I :whereinR' is hydrogen or a C1-C4 alkyl group either unsubstituted or substituted by one or more substituents chosen from a free or protected hydroxy or halogen atom;R2 is a free or esterified carboxy group or carboxylate anion;R3 and R4 are each indepe...

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Hauptverfasser: MARKO ALPEDZHANI,IT, FRANKO ZARINI,IT, KONSTANTINO DELLA BRUNA,IT, DZHOVANNI FRANCHESKI,IT, ETTORE PERRONE,IT, ANDZHELO BEDESKI,IT
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creator MARKO ALPEDZHANI,IT
FRANKO ZARINI,IT
KONSTANTINO DELLA BRUNA,IT
DZHOVANNI FRANCHESKI,IT
ETTORE PERRONE,IT
ANDZHELO BEDESKI,IT
description There are provided compounds of formula I :whereinR' is hydrogen or a C1-C4 alkyl group either unsubstituted or substituted by one or more substituents chosen from a free or protected hydroxy or halogen atom;R2 is a free or esterified carboxy group or carboxylate anion;R3 and R4 are each independently hydrogen or organic group,X is,-S-,Q is either(a") free or protected hydroxy, or(b") a C1-C4 acyloxy, or(c") carbamoyloxy OCONH2, or(d") an optionally substituted heterocyclylthio group, or(e") an optionally substituted imido group, or(f") an optionally substituted quaternary ammonium group or(g") a halogen atom, and the pharmaceutically or veterinarily acceptable salts thereof.There are provided also methods for preparing compounds of formula 1. The compounds of formula I are useful as antibacterial agents.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title METHOD OF OBTAINING DERIVATIVES OF PHENEM OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS
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