3-METHYLENE STEROID DERIVATIVE FOR THE TREATMENT OF AUTOIMMUNE DISEASES
The invention concerns a 3-methylene steroid derivative having general formula (1) wherein R1 is H or together with R3 forms a beta-epoxide or R1 is absent if there is a 5-10 or 4-5 double bond; R2 is (C1-C5) alkyl or CF3; R3 is betaH, betaCH3 or together with R1 forms a beta-epoxide or R3 is absent...
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| creator | BAGCHUS WILHELMINA MARIA PLATE RALF |
| description | The invention concerns a 3-methylene steroid derivative having general formula (1) wherein R1 is H or together with R3 forms a beta-epoxide or R1 is absent if there is a 5-10 or 4-5 double bond; R2 is (C1-C5) alkyl or CF3; R3 is betaH, betaCH3 or together with R1 forms a beta-epoxide or R3 is absent if there is a 5-10 double bond; R4 is H, lower alkyl; Y is [H, H], [OH, H], =O, [OH, lower alkyl], [OH, (C2-C5)alkenyl], [OH, (C2-C5)alkynyl] or (C1-C6) alkylidene, whereby said alkyl, alkenyl, alkynyl and alkylidene is optionally halogenated; =NOR5, whereby R5 is H, lower alkyl; dotted lines represent an optional double bond, or prodrugs thereof for the treatment of arthritic diseases and/or autoimmune diseases. |
| format | Patent |
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R2 is (C1-C5) alkyl or CF3; R3 is betaH, betaCH3 or together with R1 forms a beta-epoxide or R3 is absent if there is a 5-10 double bond; R4 is H, lower alkyl; Y is [H, H], [OH, H], =O, [OH, lower alkyl], [OH, (C2-C5)alkenyl], [OH, (C2-C5)alkynyl] or (C1-C6) alkylidene, whereby said alkyl, alkenyl, alkynyl and alkylidene is optionally halogenated; =NOR5, whereby R5 is H, lower alkyl; dotted lines represent an optional double bond, or prodrugs thereof for the treatment of arthritic diseases and/or autoimmune diseases.</description><edition>7</edition><language>eng</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; STEROIDS</subject><creationdate>2002</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20020910&DB=EPODOC&CC=SK&NR=7272002A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20020910&DB=EPODOC&CC=SK&NR=7272002A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BAGCHUS WILHELMINA MARIA</creatorcontrib><creatorcontrib>PLATE RALF</creatorcontrib><title>3-METHYLENE STEROID DERIVATIVE FOR THE TREATMENT OF AUTOIMMUNE DISEASES</title><description>The invention concerns a 3-methylene steroid derivative having general formula (1) wherein R1 is H or together with R3 forms a beta-epoxide or R1 is absent if there is a 5-10 or 4-5 double bond; R2 is (C1-C5) alkyl or CF3; R3 is betaH, betaCH3 or together with R1 forms a beta-epoxide or R3 is absent if there is a 5-10 double bond; R4 is H, lower alkyl; Y is [H, H], [OH, H], =O, [OH, lower alkyl], [OH, (C2-C5)alkenyl], [OH, (C2-C5)alkynyl] or (C1-C6) alkylidene, whereby said alkyl, alkenyl, alkynyl and alkylidene is optionally halogenated; =NOR5, whereby R5 is H, lower alkyl; dotted lines represent an optional double bond, or prodrugs thereof for the treatment of arthritic diseases and/or autoimmune diseases.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>STEROIDS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2002</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNy7EKwjAURuEsDqK-w32BQkmGzsH8MUHTQHJbcCpFrpNoob4_OvgATmf5zladTJPA4XpBD6qMkqMjhxJHy3EE-VyIA4gLLCf0TNmTHTjHlIbv4mKFrah7tbnPj1UOv-4UefAxNLK8JlmX-SZPeU_13OlOt622xvxBPo8aLFI</recordid><startdate>20020910</startdate><enddate>20020910</enddate><creator>BAGCHUS WILHELMINA MARIA</creator><creator>PLATE RALF</creator><scope>EVB</scope></search><sort><creationdate>20020910</creationdate><title>3-METHYLENE STEROID DERIVATIVE FOR THE TREATMENT OF AUTOIMMUNE DISEASES</title><author>BAGCHUS WILHELMINA MARIA ; PLATE RALF</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_SK7272002A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2002</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>STEROIDS</topic><toplevel>online_resources</toplevel><creatorcontrib>BAGCHUS WILHELMINA MARIA</creatorcontrib><creatorcontrib>PLATE RALF</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BAGCHUS WILHELMINA MARIA</au><au>PLATE RALF</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>3-METHYLENE STEROID DERIVATIVE FOR THE TREATMENT OF AUTOIMMUNE DISEASES</title><date>2002-09-10</date><risdate>2002</risdate><abstract>The invention concerns a 3-methylene steroid derivative having general formula (1) wherein R1 is H or together with R3 forms a beta-epoxide or R1 is absent if there is a 5-10 or 4-5 double bond; R2 is (C1-C5) alkyl or CF3; R3 is betaH, betaCH3 or together with R1 forms a beta-epoxide or R3 is absent if there is a 5-10 double bond; R4 is H, lower alkyl; Y is [H, H], [OH, H], =O, [OH, lower alkyl], [OH, (C2-C5)alkenyl], [OH, (C2-C5)alkynyl] or (C1-C6) alkylidene, whereby said alkyl, alkenyl, alkynyl and alkylidene is optionally halogenated; =NOR5, whereby R5 is H, lower alkyl; dotted lines represent an optional double bond, or prodrugs thereof for the treatment of arthritic diseases and/or autoimmune diseases.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS STEROIDS |
| title | 3-METHYLENE STEROID DERIVATIVE FOR THE TREATMENT OF AUTOIMMUNE DISEASES |
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