Process for preparation of (R)-(-)-2-hydroxy-2-(2- chlorophenyl)acetic acid and its salt

Process for preparation of (R)-(-)-2-hydroxy-2-(2- chlorophenyl)acetic acid and its salt

It is described a process for the preparation of (R)-(-)-2-hydroxy-2-(2-chlorophenyl)acetic acid of the general formula (I), wherein the racemic 2-hydroxy-2-(2- chlorophenyl)acetic acid is resolved with a substituted amine of the general formula (II), where R21means hydroxymethyl group or carboxyl g...

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Bibliographische Detailangaben
Hauptverfasser: CSATARINE NAGY MARIANNA, DOMBRADY ZSOLT, FOGASSY ELEMER, BALINT JOZSEF, GAJARY ANTAL, SUBA CHARLES
Format: Patent
Sprache:eng ; slo
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:It is described a process for the preparation of (R)-(-)-2-hydroxy-2-(2-chlorophenyl)acetic acid of the general formula (I), wherein the racemic 2-hydroxy-2-(2- chlorophenyl)acetic acid is resolved with a substituted amine of the general formula (II), where R21means hydroxymethyl group or carboxyl group, R2 means phenyl group, nitrophenyl group or a C1-C4 alkyl group substituted with an amino group, R3 means hydroxyl group or hydrogen atom. It is described a process for the preparation of (R)-(-)-2-hydroxy-2-(2-chlorophenyl)acetic acid of the general formula (I), wherein the racemic 2-hydroxy-2-(2- chlorophenyl)acetic acid is resolved with a substituted amine of the general formula (II), where R21means hydroxymethyl group or carboxyl group, R2 means phenyl group, nitrophenyl group or a C1-C4 alkyl group substituted with an amino group, R3 means hydroxyl group or hydrogen atom.