OXAZOLE DERIVATIVES METHOD OF THEIR PRODUCTION AND ANTIALERGIC PREPARATIONS ON THEIR BASE

Compounds of general formula I, where surplus -A1=A2-A3=A4- is -CH=CH-CH=CH-; -N=CH-CH=CH-; -CH=N-CH=CH-; -CH=CH-CH-N-; -N=CH-N=CH-CH=N-CH=N-; R is hydrogen or C1-4alkyl; R1 is hydrogen, C1-6alkyl or hydroxy C1-6alkyl; m is number 1 or 2; D is C1-4alkandiyl, B is NR2, CH2, O, S or SO, where R2 is hy...

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Hauptverfasser: DIERCKX ANN CHRISTINA J, SOMMEN FRANCOIS M, COOYMANS LUDWIG P, JANSSENS FRANS E
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creator DIERCKX ANN CHRISTINA J
SOMMEN FRANCOIS M
COOYMANS LUDWIG P
JANSSENS FRANS E
description Compounds of general formula I, where surplus -A1=A2-A3=A4- is -CH=CH-CH=CH-; -N=CH-CH=CH-; -CH=N-CH=CH-; -CH=CH-CH-N-; -N=CH-N=CH-CH=N-CH=N-; R is hydrogen or C1-4alkyl; R1 is hydrogen, C1-6alkyl or hydroxy C1-6alkyl; m is number 1 or 2; D is C1-4alkandiyl, B is NR2, CH2, O, S or SO, where R2 is hydrogen or C1-4alkyl; n is number 0,1, or 2; L is hydrogen C1-12alkyl; C3-6cycloalkyl; C3-6alkenyl; or casually substituted with aryl; C1-6alkylcarbonyl; C1-6alkoxycarbonyl, arylcarbonyl, aryl C1- -6alkoxycarbonyl or surplus of general formula -Alk-R3; -Alk-Y- -R4; Alk-Z1-C(=X)-Z2-R5; -CH2-CHOH-CH2-O-R6, their pharmaceutical suitable additive salts and stereoisomers display antialergical properties. Next is described the method of their production and antialergical preparations on their base.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title OXAZOLE DERIVATIVES METHOD OF THEIR PRODUCTION AND ANTIALERGIC PREPARATIONS ON THEIR BASE
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