OIL-WATER EMULSION OF X-RAY CONTRAST PREPARATION FOR PARENTERAL ADMINISTERING, STABLE DURING HEAT STERILISATION
The invention concerns a parenterally administerable oil-in-water emulsion for use as an X-ray contrasting agent which is stable to sterilization by heat, the emulsion having an inner phase consisting of one or more suitable oil-soluble iodinated fatty-acid esters, optionally together with one or mo...
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| creator | ESCHENBACH BERND SOMMERMEYER KLAUS FOTH HEINO |
| description | The invention concerns a parenterally administerable oil-in-water emulsion for use as an X-ray contrasting agent which is stable to sterilization by heat, the emulsion having an inner phase consisting of one or more suitable oil-soluble iodinated fatty-acid esters, optionally together with one or more highly refined glyceride oils, plus one or more emulsifiers and optionally co-emulsifiers, and an outer phase consisting of distilled water plus isotonization additives and a physiologically tolerable buffer made up of 0 to 12 mMol/l of sodium hydroxide and 2 to 10 mMol/l of sodium carbonate and/or sodium hydrogen carbonate, in each case relative to the volume of the made-up emulsion. The mean droplet size in the inner phase of the emulsion can be adjusted to any value over the range 0.2 to 4.0 mu m, and the emulsion exhibits very good stability on storage and to heat, thus enabling it to be sterilized in an autoclave at 121 DEG C for 15 to 25 minutes. |
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The mean droplet size in the inner phase of the emulsion can be adjusted to any value over the range 0.2 to 4.0 mu m, and the emulsion exhibits very good stability on storage and to heat, thus enabling it to be sterilized in an autoclave at 121 DEG C for 15 to 25 minutes.</description><edition>5</edition><language>eng</language><subject>ADHESIVES ; CHEMISTRY ; DYES ; HUMAN NECESSITIES ; HYGIENE ; MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FORELSEWHERE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MISCELLANEOUS APPLICATIONS OF MATERIALS ; MISCELLANEOUS COMPOSITIONS ; NATURAL RESINS ; PAINTS ; POLISHES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>1994</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19941231&DB=EPODOC&CC=SI&NR=9400228A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76419</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19941231&DB=EPODOC&CC=SI&NR=9400228A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ESCHENBACH BERND</creatorcontrib><creatorcontrib>SOMMERMEYER KLAUS</creatorcontrib><creatorcontrib>FOTH HEINO</creatorcontrib><title>OIL-WATER EMULSION OF X-RAY CONTRAST PREPARATION FOR PARENTERAL ADMINISTERING, STABLE DURING HEAT STERILISATION</title><description>The invention concerns a parenterally administerable oil-in-water emulsion for use as an X-ray contrasting agent which is stable to sterilization by heat, the emulsion having an inner phase consisting of one or more suitable oil-soluble iodinated fatty-acid esters, optionally together with one or more highly refined glyceride oils, plus one or more emulsifiers and optionally co-emulsifiers, and an outer phase consisting of distilled water plus isotonization additives and a physiologically tolerable buffer made up of 0 to 12 mMol/l of sodium hydroxide and 2 to 10 mMol/l of sodium carbonate and/or sodium hydrogen carbonate, in each case relative to the volume of the made-up emulsion. 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The mean droplet size in the inner phase of the emulsion can be adjusted to any value over the range 0.2 to 4.0 mu m, and the emulsion exhibits very good stability on storage and to heat, thus enabling it to be sterilized in an autoclave at 121 DEG C for 15 to 25 minutes.</abstract><edition>5</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ADHESIVES CHEMISTRY DYES HUMAN NECESSITIES HYGIENE MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FORELSEWHERE MEDICAL OR VETERINARY SCIENCE METALLURGY MISCELLANEOUS APPLICATIONS OF MATERIALS MISCELLANEOUS COMPOSITIONS NATURAL RESINS PAINTS POLISHES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | OIL-WATER EMULSION OF X-RAY CONTRAST PREPARATION FOR PARENTERAL ADMINISTERING, STABLE DURING HEAT STERILISATION |
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