BENZAZEPINE DERIVATIVES USEFUL AS MEDICAMENTS

The present invention provides novel benzazepine compounds of Formula (1), or salts thereof, having vasopressin V1a and V2 antagonisms, for use in the treatment, prevention, and/or diagnosis of a disease selected from the group consisting of Meniere's disease, hypertension, edema, ascites, hear...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Kan Keizo, Urushima Tatsuya, Tanaka Hirotaka, Fujiwara Hideto, Ohdachi Kazuhiro, Yamabe Hokuto, Matsuda Satoshi, Hanari Taiki, Takuwa Masatoshi, Menjo Yasuhiro, Fujita Shigekazu
Format: Patent
Sprache:eng ; slv
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The present invention provides novel benzazepine compounds of Formula (1), or salts thereof, having vasopressin V1a and V2 antagonisms, for use in the treatment, prevention, and/or diagnosis of a disease selected from the group consisting of Meniere's disease, hypertension, edema, ascites, heart failure, renal dysfunction, renal failure, polycystic kidney disease, syndrome of inappropriate vasopressin secretion, hepatic cirrhosis, hyponatremia, hypokalemia, diabetes, circulation insufficiency, kinesia, water metabolism disorder, and ischemic disorder.In the formula, R1 is optionally substituted C1-6 alkyl, etc.; L is -C(=O)-NH-, etc.; Ring A1 is a hydrocarbon ring, etc.; Ring A2 is a hydrocarbon ring, etc.; and each of Rings A1 and A2 may have at least one substituent.