8-(6-(3-(AMINO)PROPOXY)-3-PYRIDYL)-1-ISOPROPYL-IMIDAZO(4,5-C)QUINOLIN-2-ONE DERIVATIVES AS SELECTIVE MODULATORS OF ATAXIA TELANGIECTASIA MUTATED (ATM) KINASE FOR THE TREATMENT OF CANCER

8-(6-(3-(AMINO)PROPOXY)-3-PYRIDYL)-1-ISOPROPYL-IMIDAZO(4,5-C)QUINOLIN-2-ONE DERIVATIVES AS SELECTIVE MODULATORS OF ATAXIA TELANGIECTASIA MUTATED (ATM) KINASE FOR THE TREATMENT OF CANCER

The specification generally relates to compounds of Formula(I):and pharmaceutically acceptable salts thereof, whereR1,R2,R3,R4andR5have any of the meanings defined herein, for use in the treatment of Huntington's disease.

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Bibliographische Detailangaben
Hauptverfasser: PIKE Kurt Gordon, EATHERTON Andrew John, HUNT Thomas Anthony, BARLAAM Bernard Christophe
Format: Patent
Sprache:eng ; slv
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The specification generally relates to compounds of Formula(I):and pharmaceutically acceptable salts thereof, whereR1,R2,R3,R4andR5have any of the meanings defined herein, for use in the treatment of Huntington's disease.