NOVEL COMPOUNDS AS ROR GAMMA MODULATORS
The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, ring B, L, R1, R2, R3, R4, R5, Ra, Rb, n, m, p and q are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compound...
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| creator | GHARAT Laxmikant Atmaram HARDE Rajendra Laxman PARDESHI Shailesh Ramesh THOMAS Abraham SHELKE Sandeep Yadunath BAJPAI Malini DAS Sanjib SHAH Daisy Manish KHAIRATKAR-JOSHI Neelima |
| description | The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, ring B, L, R1, R2, R3, R4, R5, Ra, Rb, n, m, p and q are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer. |
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These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.</description><language>eng ; slv</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200731&DB=EPODOC&CC=SI&NR=3331863T1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200731&DB=EPODOC&CC=SI&NR=3331863T1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GHARAT Laxmikant Atmaram</creatorcontrib><creatorcontrib>HARDE Rajendra Laxman</creatorcontrib><creatorcontrib>PARDESHI Shailesh Ramesh</creatorcontrib><creatorcontrib>THOMAS Abraham</creatorcontrib><creatorcontrib>SHELKE Sandeep Yadunath</creatorcontrib><creatorcontrib>BAJPAI Malini</creatorcontrib><creatorcontrib>DAS Sanjib</creatorcontrib><creatorcontrib>SHAH Daisy Manish</creatorcontrib><creatorcontrib>KHAIRATKAR-JOSHI Neelima</creatorcontrib><title>NOVEL COMPOUNDS AS ROR GAMMA MODULATORS</title><description>The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, ring B, L, R1, R2, R3, R4, R5, Ra, Rb, n, m, p and q are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFD38w9z9VFw9vcN8A_1cwlWcAxWCPIPUnB39PV1VPD1dwn1cQzxDwrmYWBNS8wpTuWF0twMim6uIc4euqkF-fGpxQWJyal5qSXxwZ7GxsaGFmbGISGGxsSoAQD2ESRa</recordid><startdate>20200731</startdate><enddate>20200731</enddate><creator>GHARAT Laxmikant Atmaram</creator><creator>HARDE Rajendra Laxman</creator><creator>PARDESHI Shailesh Ramesh</creator><creator>THOMAS Abraham</creator><creator>SHELKE Sandeep Yadunath</creator><creator>BAJPAI Malini</creator><creator>DAS Sanjib</creator><creator>SHAH Daisy Manish</creator><creator>KHAIRATKAR-JOSHI Neelima</creator><scope>EVB</scope></search><sort><creationdate>20200731</creationdate><title>NOVEL COMPOUNDS AS ROR GAMMA MODULATORS</title><author>GHARAT Laxmikant Atmaram ; HARDE Rajendra Laxman ; PARDESHI Shailesh Ramesh ; THOMAS Abraham ; SHELKE Sandeep Yadunath ; BAJPAI Malini ; DAS Sanjib ; SHAH Daisy Manish ; KHAIRATKAR-JOSHI Neelima</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_SI3331863TT13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; slv</language><creationdate>2020</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>GHARAT Laxmikant Atmaram</creatorcontrib><creatorcontrib>HARDE Rajendra Laxman</creatorcontrib><creatorcontrib>PARDESHI Shailesh Ramesh</creatorcontrib><creatorcontrib>THOMAS Abraham</creatorcontrib><creatorcontrib>SHELKE Sandeep Yadunath</creatorcontrib><creatorcontrib>BAJPAI Malini</creatorcontrib><creatorcontrib>DAS Sanjib</creatorcontrib><creatorcontrib>SHAH Daisy Manish</creatorcontrib><creatorcontrib>KHAIRATKAR-JOSHI Neelima</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GHARAT Laxmikant Atmaram</au><au>HARDE Rajendra Laxman</au><au>PARDESHI Shailesh Ramesh</au><au>THOMAS Abraham</au><au>SHELKE Sandeep Yadunath</au><au>BAJPAI Malini</au><au>DAS Sanjib</au><au>SHAH Daisy Manish</au><au>KHAIRATKAR-JOSHI Neelima</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NOVEL COMPOUNDS AS ROR GAMMA MODULATORS</title><date>2020-07-31</date><risdate>2020</risdate><abstract>The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, ring B, L, R1, R2, R3, R4, R5, Ra, Rb, n, m, p and q are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | NOVEL COMPOUNDS AS ROR GAMMA MODULATORS |
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