PROCESS FOR THE PREPARATION OF POLYMYXIN B EMPLOYING (PAENI)BACILLUS POLYMYXA

PROCESS FOR THE PREPARATION OF POLYMYXIN B EMPLOYING (PAENI)BACILLUS POLYMYXA

The invention is related to the process of fermentation with production strain Bacillus polymyxa for industrial production of antibiotic polymyxin B with yield from 1.8 to 2.8 g/l of filtrate of fermentation broth at temperature 28° C., pressure 40−70 kPa, aeration from 0.4 to 1 vvm, concentration o...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: VARGA IVAN, KOVACOVA LUDMILA, KLUKOVA JANA, VRUBLOVA KATARINA
Format: Patent
Sprache:eng ; slv
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The invention is related to the process of fermentation with production strain Bacillus polymyxa for industrial production of antibiotic polymyxin B with yield from 1.8 to 2.8 g/l of filtrate of fermentation broth at temperature 28° C., pressure 40−70 kPa, aeration from 0.4 to 1 vvm, concentration of dissolved oxygen minimal 60%, maintenance of pH and optimal concentration of glucose and ammonium ions.