Process for stepwise attachment of polyethylene glycol (PEG) to a polypeptide

Process for stepwise attachment of polyethylene glycol (PEG) to a polypeptide

PEG-IFN- beta conjugates, where a PEG moiety is covalently bound to Cys of human IFN- beta , are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory disease...

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Hauptverfasser: ROBERTS MICHAEL J, SAWLIVICH WAYNE, EL TAYAR NABIL, HARRIS MILTON
Format: Patent
Sprache:eng ; slv
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator ROBERTS MICHAEL J
SAWLIVICH WAYNE
EL TAYAR NABIL
HARRIS MILTON
description PEG-IFN- beta conjugates, where a PEG moiety is covalently bound to Cys of human IFN- beta , are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further relates to a method for the stepwise attachment of PEG moieties in series to a polypeptide, and more particularly to IFN- beta .
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Process for stepwise attachment of polyethylene glycol (PEG) to a polypeptide
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