METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS USING ISOINDOLINE DERIVATIVES

METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS USING ISOINDOLINE DERIVATIVES

The present invention provides a method of treating Alzheimer's disease using a novel compound of formula (I), wherein X is phenyl or substituted phenyl; Y is phenyl, substituted phenyl, pyridyl, or substituted pyridyl. Also provided is a method of inhibiting the aggregation of amyloid proteins...

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Hauptverfasser: SAKKAB ANNETTE THERESA, LAI YINGJIE, WALKER LARY CRASWELL, AUGELLI-SZAFRAN CORINNE ELIZABETH
Format: Patent
Sprache:eng ; slv
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator SAKKAB ANNETTE THERESA
LAI YINGJIE
WALKER LARY CRASWELL
AUGELLI-SZAFRAN CORINNE ELIZABETH
description The present invention provides a method of treating Alzheimer's disease using a novel compound of formula (I), wherein X is phenyl or substituted phenyl; Y is phenyl, substituted phenyl, pyridyl, or substituted pyridyl. Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound of formula (I) and a method of imaging amyloid deposits using isoindoline derivatives.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS USING ISOINDOLINE DERIVATIVES
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