Substituted heterocyclic benzocycloalkenes and their use as analgesically active compounds
Aminomethyl substituted heterocyclic benzocycloalkene derivatives (I) are new. Aminomethyl substituted heterocyclic benzocycloalkene derivatives of formula (I) and their salts are new: R = OH; 1-6C alkoxy; or 3-7C cycloalkyloxy; R = 1-6C alkyl; R = 1-6C alkyl; aryl-1-2C alkyl; heterocyclyl-1-2C alky...
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| creator | ZIMMER OSWALD DR PUETZ CLAUDIA DR STRASSBURGER WOLFGANG DR ENGLBERGER WERNER DR KOEGEL BABETTE-YVONNE DR |
| description | Aminomethyl substituted heterocyclic benzocycloalkene derivatives (I) are new. Aminomethyl substituted heterocyclic benzocycloalkene derivatives of formula (I) and their salts are new: R = OH; 1-6C alkoxy; or 3-7C cycloalkyloxy; R = 1-6C alkyl; R = 1-6C alkyl; aryl-1-2C alkyl; heterocyclyl-1-2C alkyl; -CH2-CH=C(R )2; or 3-7C cycloalkyl-methyl; R , R = H; Cl; F; CF3; 1-6C alkyl; OH; 1-6C alkoxy; 3-7C cycloalkyloxy; alpha , beta or beta , gamma -O-(CH2)o-O-; -(CH2)n-aryl; heterocyclyl; -O-(CH2)n-aryl; or alpha , beta - or beta , gamma -benzo optionally mono- or disubstituted by F, Cl, CF3, OH, 1-6C alkyl, 1-6C alkoxy or -CON(R R ); R = H or 1-6C alkyl; R = H; 1-6C alkyl; -(CH2)naryl; or CH2-3-7C cycloalkyl; or R + R = -(CH2)m or -(CH2)2-O-(CH2)2-; X = O; S; SO; or SO2; Y = -(CH2)0; -CH2-C(CH3)2-; or -C(CH3)2-; n = 0-2; m = 5-7; o = 1-2. An Independent claim is included for the preparation of compounds (I). |
| format | Patent |
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Aminomethyl substituted heterocyclic benzocycloalkene derivatives of formula (I) and their salts are new: R = OH; 1-6C alkoxy; or 3-7C cycloalkyloxy; R = 1-6C alkyl; R = 1-6C alkyl; aryl-1-2C alkyl; heterocyclyl-1-2C alkyl; -CH2-CH=C(R )2; or 3-7C cycloalkyl-methyl; R , R = H; Cl; F; CF3; 1-6C alkyl; OH; 1-6C alkoxy; 3-7C cycloalkyloxy; alpha , beta or beta , gamma -O-(CH2)o-O-; -(CH2)n-aryl; heterocyclyl; -O-(CH2)n-aryl; or alpha , beta - or beta , gamma -benzo optionally mono- or disubstituted by F, Cl, CF3, OH, 1-6C alkyl, 1-6C alkoxy or -CON(R R ); R = H or 1-6C alkyl; R = H; 1-6C alkyl; -(CH2)naryl; or CH2-3-7C cycloalkyl; or R + R = -(CH2)m or -(CH2)2-O-(CH2)2-; X = O; S; SO; or SO2; Y = -(CH2)0; -CH2-C(CH3)2-; or -C(CH3)2-; n = 0-2; m = 5-7; o = 1-2. 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Aminomethyl substituted heterocyclic benzocycloalkene derivatives of formula (I) and their salts are new: R = OH; 1-6C alkoxy; or 3-7C cycloalkyloxy; R = 1-6C alkyl; R = 1-6C alkyl; aryl-1-2C alkyl; heterocyclyl-1-2C alkyl; -CH2-CH=C(R )2; or 3-7C cycloalkyl-methyl; R , R = H; Cl; F; CF3; 1-6C alkyl; OH; 1-6C alkoxy; 3-7C cycloalkyloxy; alpha , beta or beta , gamma -O-(CH2)o-O-; -(CH2)n-aryl; heterocyclyl; -O-(CH2)n-aryl; or alpha , beta - or beta , gamma -benzo optionally mono- or disubstituted by F, Cl, CF3, OH, 1-6C alkyl, 1-6C alkoxy or -CON(R R ); R = H or 1-6C alkyl; R = H; 1-6C alkyl; -(CH2)naryl; or CH2-3-7C cycloalkyl; or R + R = -(CH2)m or -(CH2)2-O-(CH2)2-; X = O; S; SO; or SO2; Y = -(CH2)0; -CH2-C(CH3)2-; or -C(CH3)2-; n = 0-2; m = 5-7; o = 1-2. 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Aminomethyl substituted heterocyclic benzocycloalkene derivatives of formula (I) and their salts are new: R = OH; 1-6C alkoxy; or 3-7C cycloalkyloxy; R = 1-6C alkyl; R = 1-6C alkyl; aryl-1-2C alkyl; heterocyclyl-1-2C alkyl; -CH2-CH=C(R )2; or 3-7C cycloalkyl-methyl; R , R = H; Cl; F; CF3; 1-6C alkyl; OH; 1-6C alkoxy; 3-7C cycloalkyloxy; alpha , beta or beta , gamma -O-(CH2)o-O-; -(CH2)n-aryl; heterocyclyl; -O-(CH2)n-aryl; or alpha , beta - or beta , gamma -benzo optionally mono- or disubstituted by F, Cl, CF3, OH, 1-6C alkyl, 1-6C alkoxy or -CON(R R ); R = H or 1-6C alkyl; R = H; 1-6C alkyl; -(CH2)naryl; or CH2-3-7C cycloalkyl; or R + R = -(CH2)m or -(CH2)2-O-(CH2)2-; X = O; S; SO; or SO2; Y = -(CH2)0; -CH2-C(CH3)2-; or -C(CH3)2-; n = 0-2; m = 5-7; o = 1-2. An Independent claim is included for the preparation of compounds (I).</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Substituted heterocyclic benzocycloalkenes and their use as analgesically active compounds |
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