Cycloalkano-indole- and -azaindole derivatives
Cycloalkano-indole derivs. and aza analogues of formula (I) and isomers and salts are new. R1-C=C-R2 = phenyl, pyridyl or a gp. of formula (a), all opt. substd. by 1-3 gps. R'; R8 = H or 1-4C alkyl; R3-C=C-R4 = phenyl, 4-8C cycloalkene or 4-8 membered oxocycloalkane (all opt. substd. by 1-3 gps...
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| creator | DENZER DIRK DR GRUETZMANN RUDI DR WOHLFEIL STEFAN DR DOMDEY-BETTE ANKE DR BISCHOFF HILMAR DR CONNELL RICHARD DR BEUCK MARTIN DR MUELLER ULRICH DR GOLDMANN SIEGFRIED DR |
| description | Cycloalkano-indole derivs. and aza analogues of formula (I) and isomers and salts are new. R1-C=C-R2 = phenyl, pyridyl or a gp. of formula (a), all opt. substd. by 1-3 gps. R'; R8 = H or 1-4C alkyl; R3-C=C-R4 = phenyl, 4-8C cycloalkene or 4-8 membered oxocycloalkane (all opt. substd. by 1-3 gps. R'); R' = independently halo, CF3, COOH, OH, up to 6C alkoxy carbonyl, 1-6C alkoxy, or 1-6C alkyl (opt. substd. by OH or 1-4C alkoxy); R = H, 4-12C cycloalkyl or 1-12C alkyl; A = CO or CS; X = O, S or NR9; R9 = H or 1-6C alkyl (opt. substd. by OH or phenyl); R5 = phenyl or 5-8 membered, opt. unsatd. heterocyclic with 1-3 heteroatoms (S, N and/or O), (both opt. mono- to tri-substd. by NO2, COOH, halo, CN, 2-6C alkenyl, 1-6C alkoxy or alkyl (opt. substd. by OH, COOH, 1-6C alkoxy or up to 6C alkoxycarbonyl; and/or opt. mono- substd. by OR10 or NR11R12); R10 = H, 1-6C alkyl or 2-6C alkenyl; R11, R12 = H, phenyl, 1-6C alkyl, or up to 8C acyl (opt. subst. by NR13R14); R13, R14 = H or up to 8C acyl; R7 = H; R6 = H, COOH, 1-5 alkoxy, or 1-6C alkyl (opt. substd. by OH or OCOR15); or R6+R7 = O; R = phenyl (opt. mono- to tri-substd., by halo, OH or 1-5C alkyl), or 1-22C alkyl or 2-22C alkenyl (both opt. substd. by OR16); R16 = H, benzyl, triphenylmethyl or up to 6C acyl. Also claimed are intermediates of formula (II). |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_SI0705831TT1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>SI0705831TT1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_SI0705831TT13</originalsourceid><addsrcrecordid>eNrjZNBzrkzOyU_MyU7My9fNzEvJz0nVVUjMS1HQTaxKhPAVUlKLMssSSzLLUot5GFjTEnOKU3mhNDeDoptriLOHbmpBfnxqcUFicmpeakl8sKeBuYGphbFhSIihMTFqAPikKu0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Cycloalkano-indole- and -azaindole derivatives</title><source>esp@cenet</source><creator>DENZER DIRK DR ; GRUETZMANN RUDI DR ; WOHLFEIL STEFAN DR ; DOMDEY-BETTE ANKE DR ; BISCHOFF HILMAR DR ; CONNELL RICHARD DR ; BEUCK MARTIN DR ; MUELLER ULRICH DR ; GOLDMANN SIEGFRIED DR</creator><creatorcontrib>DENZER DIRK DR ; GRUETZMANN RUDI DR ; WOHLFEIL STEFAN DR ; DOMDEY-BETTE ANKE DR ; BISCHOFF HILMAR DR ; CONNELL RICHARD DR ; BEUCK MARTIN DR ; MUELLER ULRICH DR ; GOLDMANN SIEGFRIED DR</creatorcontrib><description>Cycloalkano-indole derivs. and aza analogues of formula (I) and isomers and salts are new. R1-C=C-R2 = phenyl, pyridyl or a gp. of formula (a), all opt. substd. by 1-3 gps. R'; R8 = H or 1-4C alkyl; R3-C=C-R4 = phenyl, 4-8C cycloalkene or 4-8 membered oxocycloalkane (all opt. substd. by 1-3 gps. R'); R' = independently halo, CF3, COOH, OH, up to 6C alkoxy carbonyl, 1-6C alkoxy, or 1-6C alkyl (opt. substd. by OH or 1-4C alkoxy); R = H, 4-12C cycloalkyl or 1-12C alkyl; A = CO or CS; X = O, S or NR9; R9 = H or 1-6C alkyl (opt. substd. by OH or phenyl); R5 = phenyl or 5-8 membered, opt. unsatd. heterocyclic with 1-3 heteroatoms (S, N and/or O), (both opt. mono- to tri-substd. by NO2, COOH, halo, CN, 2-6C alkenyl, 1-6C alkoxy or alkyl (opt. substd. by OH, COOH, 1-6C alkoxy or up to 6C alkoxycarbonyl; and/or opt. mono- substd. by OR10 or NR11R12); R10 = H, 1-6C alkyl or 2-6C alkenyl; R11, R12 = H, phenyl, 1-6C alkyl, or up to 8C acyl (opt. subst. by NR13R14); R13, R14 = H or up to 8C acyl; R7 = H; R6 = H, COOH, 1-5 alkoxy, or 1-6C alkyl (opt. substd. by OH or OCOR15); or R6+R7 = O; R = phenyl (opt. mono- to tri-substd., by halo, OH or 1-5C alkyl), or 1-22C alkyl or 2-22C alkenyl (both opt. substd. by OR16); R16 = H, benzyl, triphenylmethyl or up to 6C acyl. Also claimed are intermediates of formula (II).</description><edition>7</edition><language>eng ; slv</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2004</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040229&DB=EPODOC&CC=SI&NR=0705831T1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040229&DB=EPODOC&CC=SI&NR=0705831T1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DENZER DIRK DR</creatorcontrib><creatorcontrib>GRUETZMANN RUDI DR</creatorcontrib><creatorcontrib>WOHLFEIL STEFAN DR</creatorcontrib><creatorcontrib>DOMDEY-BETTE ANKE DR</creatorcontrib><creatorcontrib>BISCHOFF HILMAR DR</creatorcontrib><creatorcontrib>CONNELL RICHARD DR</creatorcontrib><creatorcontrib>BEUCK MARTIN DR</creatorcontrib><creatorcontrib>MUELLER ULRICH DR</creatorcontrib><creatorcontrib>GOLDMANN SIEGFRIED DR</creatorcontrib><title>Cycloalkano-indole- and -azaindole derivatives</title><description>Cycloalkano-indole derivs. and aza analogues of formula (I) and isomers and salts are new. R1-C=C-R2 = phenyl, pyridyl or a gp. of formula (a), all opt. substd. by 1-3 gps. R'; R8 = H or 1-4C alkyl; R3-C=C-R4 = phenyl, 4-8C cycloalkene or 4-8 membered oxocycloalkane (all opt. substd. by 1-3 gps. R'); R' = independently halo, CF3, COOH, OH, up to 6C alkoxy carbonyl, 1-6C alkoxy, or 1-6C alkyl (opt. substd. by OH or 1-4C alkoxy); R = H, 4-12C cycloalkyl or 1-12C alkyl; A = CO or CS; X = O, S or NR9; R9 = H or 1-6C alkyl (opt. substd. by OH or phenyl); R5 = phenyl or 5-8 membered, opt. unsatd. heterocyclic with 1-3 heteroatoms (S, N and/or O), (both opt. mono- to tri-substd. by NO2, COOH, halo, CN, 2-6C alkenyl, 1-6C alkoxy or alkyl (opt. substd. by OH, COOH, 1-6C alkoxy or up to 6C alkoxycarbonyl; and/or opt. mono- substd. by OR10 or NR11R12); R10 = H, 1-6C alkyl or 2-6C alkenyl; R11, R12 = H, phenyl, 1-6C alkyl, or up to 8C acyl (opt. subst. by NR13R14); R13, R14 = H or up to 8C acyl; R7 = H; R6 = H, COOH, 1-5 alkoxy, or 1-6C alkyl (opt. substd. by OH or OCOR15); or R6+R7 = O; R = phenyl (opt. mono- to tri-substd., by halo, OH or 1-5C alkyl), or 1-22C alkyl or 2-22C alkenyl (both opt. substd. by OR16); R16 = H, benzyl, triphenylmethyl or up to 6C acyl. Also claimed are intermediates of formula (II).</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2004</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNBzrkzOyU_MyU7My9fNzEvJz0nVVUjMS1HQTaxKhPAVUlKLMssSSzLLUot5GFjTEnOKU3mhNDeDoptriLOHbmpBfnxqcUFicmpeakl8sKeBuYGphbFhSIihMTFqAPikKu0</recordid><startdate>20040229</startdate><enddate>20040229</enddate><creator>DENZER DIRK DR</creator><creator>GRUETZMANN RUDI DR</creator><creator>WOHLFEIL STEFAN DR</creator><creator>DOMDEY-BETTE ANKE DR</creator><creator>BISCHOFF HILMAR DR</creator><creator>CONNELL RICHARD DR</creator><creator>BEUCK MARTIN DR</creator><creator>MUELLER ULRICH DR</creator><creator>GOLDMANN SIEGFRIED DR</creator><scope>EVB</scope></search><sort><creationdate>20040229</creationdate><title>Cycloalkano-indole- and -azaindole derivatives</title><author>DENZER DIRK DR ; GRUETZMANN RUDI DR ; WOHLFEIL STEFAN DR ; DOMDEY-BETTE ANKE DR ; BISCHOFF HILMAR DR ; CONNELL RICHARD DR ; BEUCK MARTIN DR ; MUELLER ULRICH DR ; GOLDMANN SIEGFRIED DR</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_SI0705831TT13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; slv</language><creationdate>2004</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>DENZER DIRK DR</creatorcontrib><creatorcontrib>GRUETZMANN RUDI DR</creatorcontrib><creatorcontrib>WOHLFEIL STEFAN DR</creatorcontrib><creatorcontrib>DOMDEY-BETTE ANKE DR</creatorcontrib><creatorcontrib>BISCHOFF HILMAR DR</creatorcontrib><creatorcontrib>CONNELL RICHARD DR</creatorcontrib><creatorcontrib>BEUCK MARTIN DR</creatorcontrib><creatorcontrib>MUELLER ULRICH DR</creatorcontrib><creatorcontrib>GOLDMANN SIEGFRIED DR</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DENZER DIRK DR</au><au>GRUETZMANN RUDI DR</au><au>WOHLFEIL STEFAN DR</au><au>DOMDEY-BETTE ANKE DR</au><au>BISCHOFF HILMAR DR</au><au>CONNELL RICHARD DR</au><au>BEUCK MARTIN DR</au><au>MUELLER ULRICH DR</au><au>GOLDMANN SIEGFRIED DR</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Cycloalkano-indole- and -azaindole derivatives</title><date>2004-02-29</date><risdate>2004</risdate><abstract>Cycloalkano-indole derivs. and aza analogues of formula (I) and isomers and salts are new. R1-C=C-R2 = phenyl, pyridyl or a gp. of formula (a), all opt. substd. by 1-3 gps. R'; R8 = H or 1-4C alkyl; R3-C=C-R4 = phenyl, 4-8C cycloalkene or 4-8 membered oxocycloalkane (all opt. substd. by 1-3 gps. R'); R' = independently halo, CF3, COOH, OH, up to 6C alkoxy carbonyl, 1-6C alkoxy, or 1-6C alkyl (opt. substd. by OH or 1-4C alkoxy); R = H, 4-12C cycloalkyl or 1-12C alkyl; A = CO or CS; X = O, S or NR9; R9 = H or 1-6C alkyl (opt. substd. by OH or phenyl); R5 = phenyl or 5-8 membered, opt. unsatd. heterocyclic with 1-3 heteroatoms (S, N and/or O), (both opt. mono- to tri-substd. by NO2, COOH, halo, CN, 2-6C alkenyl, 1-6C alkoxy or alkyl (opt. substd. by OH, COOH, 1-6C alkoxy or up to 6C alkoxycarbonyl; and/or opt. mono- substd. by OR10 or NR11R12); R10 = H, 1-6C alkyl or 2-6C alkenyl; R11, R12 = H, phenyl, 1-6C alkyl, or up to 8C acyl (opt. subst. by NR13R14); R13, R14 = H or up to 8C acyl; R7 = H; R6 = H, COOH, 1-5 alkoxy, or 1-6C alkyl (opt. substd. by OH or OCOR15); or R6+R7 = O; R = phenyl (opt. mono- to tri-substd., by halo, OH or 1-5C alkyl), or 1-22C alkyl or 2-22C alkenyl (both opt. substd. by OR16); R16 = H, benzyl, triphenylmethyl or up to 6C acyl. Also claimed are intermediates of formula (II).</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Cycloalkano-indole- and -azaindole derivatives |
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