Antibacterial pyrido 1,2,3-d,e 1,3,4 benzoxacin derivatives
The present invention relates to novel pyrido[1,2,3-d,e][1,3,4]benzoxadiazine derivatives of the formula (I) in which R is hydrogen or C1-C4-alkyl which is optionally substituted by hydroxyl or halogen, R independently of R is hydrogen or methyl, R is hydrogen or C1-C4-alkyl, R is hydrogen, alkyl ha...
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| creator | PETERSEN UWE DR PHILIPPS THOMAS DR SCHENKE THOMAS DR SCHEER MARTIN DR ENDERMANN RAINER DR METZGER KARL GEORG DR WETZSTEIN HEINZ-GEORG DR MIELKE BURKHARD DR BREMM KLAUS DIETER DR STEGEMANN MICHAEL DR JAETSCH THOMAS DR |
| description | The present invention relates to novel pyrido[1,2,3-d,e][1,3,4]benzoxadiazine derivatives of the formula (I) in which R is hydrogen or C1-C4-alkyl which is optionally substituted by hydroxyl or halogen, R independently of R is hydrogen or methyl, R is hydrogen or C1-C4-alkyl, R is hydrogen, alkyl having 1 to 4 carbon atoms, which is optionally substituted by hydroxyl, methoxy, amino, methylamino or dimethylamino, or (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl, X is hydrogen or halogen, Z is a radical of the structure wherein R is hydrogen, hydroxyl, -NR R , hydroxymethyl or -CH2-NR R , carboxyl, methoxycarbonyl or ethoxycarbonyl, where R is hydrogen, C1-C3-alkyl which is optionally substituted by hydroxyl, or alkoxycarbonyl having 1 to 4 C atoms in the alkoxy moiety or C1-C3-acyl, and R is hydrogen or methyl, R is hydrogen, straight-chain or branched C1-C3-alkyl or cyclopropyl, R is hydrogen or methyl, R is hydrogen or methyl, R is hydrogen, methyl or radicals of the structures -CH=CH-CO2R, -CH2-CO-CH3, -CH2-CH2-CN, R |
| format | Patent |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Antibacterial pyrido 1,2,3-d,e 1,3,4 benzoxacin derivatives |
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