ALBUMIN VARIANTS AND CONJUGATES

ALBUMIN VARIANTS AND CONJUGATES

Based on the three-dimensional structure of albumin, the inventors have designed variant polypeptides (muteins) which have one or more cysteine residues with a free thiol group (hereinafter referred to as "thio-albumin"). The variant polypeptide may be conjugated through the sulphur atom o...

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Bibliographische Detailangaben
Hauptverfasser: HAY, JOANNA, MARY, CAMERON, JASON, SLEEP, DARRELL, FINNIS, CHRISTOPHER, JOHN, ARTHUR, FRIIS, ESBEN, PETER
Format: Patent
Sprache:eng
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Zusammenfassung:Based on the three-dimensional structure of albumin, the inventors have designed variant polypeptides (muteins) which have one or more cysteine residues with a free thiol group (hereinafter referred to as "thio-albumin"). The variant polypeptide may be conjugated through the sulphur atom of the cysteine residue to a conjugation partner such as a bioactive compound.