5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS

5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS

5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORSAbstractThe present invention relates to compounds of formula (1) or pharmaceutical acceptable salts, wherein A, R1,R2, R3 and m, are defined in the description. The present invention relates also to methods of making said compounds, and composi...

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Hauptverfasser: TEUSCH, NICOLE, AKRITOPOULOU-ZANZE, IRINI, SHUAI, QI, MACK, HELMUT, DJURIC, STEVAN W, GASIECKI, ALAN F, SARRIS, KATHY, KOVAR, PETER J, HOBSON, ADRIAN, TURNER, SEAN C, BAKKER, MARGARETHA, WANG, LU, VASUDEVAN, ANIL, ST. JOHN MOORE, NIGEL, FRANK, KRISTINE, JOHNSON, ERIC T, MICHMERHUIZEN, MELISSA J, LONG, ANDREW J, GRACIAS, VIJAYA J, PATEL, JYOTI R, WAKEFIELD, BRIAN D, LI, BIQIN, GEORGE, DAWN, KALVIN, DOUGLAS M
Format: Patent
Sprache:eng
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Zusammenfassung:5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORSAbstractThe present invention relates to compounds of formula (1) or pharmaceutical acceptable salts, wherein A, R1,R2, R3 and m, are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as Glycogen Synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janus Kinases (JAK), Ala, PAK4, PLK, CK2, KDR, MK2, JNK I, aurora, pim I and nek 2.No suitable figure