COMPOSITIONS AND METHODS FOR MINIMALLY-INVASIVE SYSTEMIC DELIVERY OF PROTEINS INCLUDING TGF-ß SUPERFAMILY MEMBERS

COMPOSITIONS AND METHODS FOR MINIMALLY-INVASIVE SYSTEMIC DELIVERY OF PROTEINS INCLUDING TGF-ß SUPERFAMILY MEMBERS

The present invention is directed to methods and compositions for systemic delivery of minimally- soluble bioactive agents such as, but not limited to, proteins of the TGF- superfamily. According to the invention, an exemplary bioactive agent is BMP-7 The invention further provides for minimally-inv...

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Hauptverfasser: PECQUET GOAD, MARY, ELIZABETH, SCHRIER, DENIS, PIERCE, ALLEN, RICHARD
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creator PECQUET GOAD, MARY, ELIZABETH
SCHRIER, DENIS
PIERCE, ALLEN, RICHARD
description The present invention is directed to methods and compositions for systemic delivery of minimally- soluble bioactive agents such as, but not limited to, proteins of the TGF- superfamily. According to the invention, an exemplary bioactive agent is BMP-7 The invention further provides for minimally-invasive systemic treatment of skeletal disorders such as osteoporosis as well as minimally-invasive systemic treatment of injured or diseased non-mineralized tissues and organs such kidneys. Practice of the invention eliminates adverse side effects at the site of intravascular delivery of the bioactive agent.
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title COMPOSITIONS AND METHODS FOR MINIMALLY-INVASIVE SYSTEMIC DELIVERY OF PROTEINS INCLUDING TGF-ß SUPERFAMILY MEMBERS
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