5-SUBSTITUTED-2-PHENYLAMINO-BENZAMIDE AS MEK INHIBITOR

5-SUBSTITUTED-2-PHENYLAMINO-BENZAMIDE AS MEK INHIBITOR

5-SUBSTITUTED-2-PHENYLAMINOBENZAMIDES AS MEK INHIBITORS An objective of the present invention is to provide compounds that exhibit strong MEK-inhibiting activity and are stable in vivo and soluble in water, which can be used as preventive or therapeutic agents for proliferative diseases. The compoun...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: MATSUBARA, YASUAKI, SHIMMA, NOBUO, MIWA, MASANORI, TSUJII, SHINJI, AIDA, SATOSHI, KOHCHI, YASUNORI, KOHCHI, MASAMI, MIZUGUCHI, EISAKU, ISSHIKI, YOSHIAKI, IIKURA, HITOSHI, MURATA, TAKESHI, ASO, KOSUKE
Format: Patent
Sprache:eng
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator MATSUBARA, YASUAKI
SHIMMA, NOBUO
MIWA, MASANORI
TSUJII, SHINJI
AIDA, SATOSHI
KOHCHI, YASUNORI
KOHCHI, MASAMI
MIZUGUCHI, EISAKU
ISSHIKI, YOSHIAKI
IIKURA, HITOSHI
MURATA, TAKESHI
ASO, KOSUKE
description 5-SUBSTITUTED-2-PHENYLAMINOBENZAMIDES AS MEK INHIBITORS An objective of the present invention is to provide compounds that exhibit strong MEK-inhibiting activity and are stable in vivo and soluble in water, which can be used as preventive or therapeutic agents for proliferative diseases. The compounds of the present invention and pharmaceutically acceptable salts thereof are represented by the following formula (1): [where R1, R2, R3, R4, and X are the same as defined in the present patent application]. (no suitable figure)
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_SG151286A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>SG151286A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_SG151286A13</originalsourceid><addsrcrecordid>eNrjZDAz1Q0OdQoO8QwJDXF10TXSDfBw9Yv0cfT19PPXdXL1iwKyXFwVHIMVfF29FTz9PDydPEP8g3gYWNMSc4pTeaE0N4O8m2uIs4duakF-fGpxQWJyal5qSXywu6GpoZGFmaOhMWEVAHyGJyI</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>5-SUBSTITUTED-2-PHENYLAMINO-BENZAMIDE AS MEK INHIBITOR</title><source>esp@cenet</source><creator>MATSUBARA, YASUAKI ; SHIMMA, NOBUO ; MIWA, MASANORI ; TSUJII, SHINJI ; AIDA, SATOSHI ; KOHCHI, YASUNORI ; KOHCHI, MASAMI ; MIZUGUCHI, EISAKU ; ISSHIKI, YOSHIAKI ; IIKURA, HITOSHI ; MURATA, TAKESHI ; ASO, KOSUKE</creator><creatorcontrib>MATSUBARA, YASUAKI ; SHIMMA, NOBUO ; MIWA, MASANORI ; TSUJII, SHINJI ; AIDA, SATOSHI ; KOHCHI, YASUNORI ; KOHCHI, MASAMI ; MIZUGUCHI, EISAKU ; ISSHIKI, YOSHIAKI ; IIKURA, HITOSHI ; MURATA, TAKESHI ; ASO, KOSUKE</creatorcontrib><description>5-SUBSTITUTED-2-PHENYLAMINOBENZAMIDES AS MEK INHIBITORS An objective of the present invention is to provide compounds that exhibit strong MEK-inhibiting activity and are stable in vivo and soluble in water, which can be used as preventive or therapeutic agents for proliferative diseases. The compounds of the present invention and pharmaceutically acceptable salts thereof are represented by the following formula (1): [where R1, R2, R3, R4, and X are the same as defined in the present patent application]. (no suitable figure)</description><language>eng</language><creationdate>2009</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20090430&amp;DB=EPODOC&amp;CC=SG&amp;NR=151286A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20090430&amp;DB=EPODOC&amp;CC=SG&amp;NR=151286A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MATSUBARA, YASUAKI</creatorcontrib><creatorcontrib>SHIMMA, NOBUO</creatorcontrib><creatorcontrib>MIWA, MASANORI</creatorcontrib><creatorcontrib>TSUJII, SHINJI</creatorcontrib><creatorcontrib>AIDA, SATOSHI</creatorcontrib><creatorcontrib>KOHCHI, YASUNORI</creatorcontrib><creatorcontrib>KOHCHI, MASAMI</creatorcontrib><creatorcontrib>MIZUGUCHI, EISAKU</creatorcontrib><creatorcontrib>ISSHIKI, YOSHIAKI</creatorcontrib><creatorcontrib>IIKURA, HITOSHI</creatorcontrib><creatorcontrib>MURATA, TAKESHI</creatorcontrib><creatorcontrib>ASO, KOSUKE</creatorcontrib><title>5-SUBSTITUTED-2-PHENYLAMINO-BENZAMIDE AS MEK INHIBITOR</title><description>5-SUBSTITUTED-2-PHENYLAMINOBENZAMIDES AS MEK INHIBITORS An objective of the present invention is to provide compounds that exhibit strong MEK-inhibiting activity and are stable in vivo and soluble in water, which can be used as preventive or therapeutic agents for proliferative diseases. The compounds of the present invention and pharmaceutically acceptable salts thereof are represented by the following formula (1): [where R1, R2, R3, R4, and X are the same as defined in the present patent application]. (no suitable figure)</description><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2009</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDAz1Q0OdQoO8QwJDXF10TXSDfBw9Yv0cfT19PPXdXL1iwKyXFwVHIMVfF29FTz9PDydPEP8g3gYWNMSc4pTeaE0N4O8m2uIs4duakF-fGpxQWJyal5qSXywu6GpoZGFmaOhMWEVAHyGJyI</recordid><startdate>20090430</startdate><enddate>20090430</enddate><creator>MATSUBARA, YASUAKI</creator><creator>SHIMMA, NOBUO</creator><creator>MIWA, MASANORI</creator><creator>TSUJII, SHINJI</creator><creator>AIDA, SATOSHI</creator><creator>KOHCHI, YASUNORI</creator><creator>KOHCHI, MASAMI</creator><creator>MIZUGUCHI, EISAKU</creator><creator>ISSHIKI, YOSHIAKI</creator><creator>IIKURA, HITOSHI</creator><creator>MURATA, TAKESHI</creator><creator>ASO, KOSUKE</creator><scope>EVB</scope></search><sort><creationdate>20090430</creationdate><title>5-SUBSTITUTED-2-PHENYLAMINO-BENZAMIDE AS MEK INHIBITOR</title><author>MATSUBARA, YASUAKI ; SHIMMA, NOBUO ; MIWA, MASANORI ; TSUJII, SHINJI ; AIDA, SATOSHI ; KOHCHI, YASUNORI ; KOHCHI, MASAMI ; MIZUGUCHI, EISAKU ; ISSHIKI, YOSHIAKI ; IIKURA, HITOSHI ; MURATA, TAKESHI ; ASO, KOSUKE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_SG151286A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2009</creationdate><toplevel>online_resources</toplevel><creatorcontrib>MATSUBARA, YASUAKI</creatorcontrib><creatorcontrib>SHIMMA, NOBUO</creatorcontrib><creatorcontrib>MIWA, MASANORI</creatorcontrib><creatorcontrib>TSUJII, SHINJI</creatorcontrib><creatorcontrib>AIDA, SATOSHI</creatorcontrib><creatorcontrib>KOHCHI, YASUNORI</creatorcontrib><creatorcontrib>KOHCHI, MASAMI</creatorcontrib><creatorcontrib>MIZUGUCHI, EISAKU</creatorcontrib><creatorcontrib>ISSHIKI, YOSHIAKI</creatorcontrib><creatorcontrib>IIKURA, HITOSHI</creatorcontrib><creatorcontrib>MURATA, TAKESHI</creatorcontrib><creatorcontrib>ASO, KOSUKE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MATSUBARA, YASUAKI</au><au>SHIMMA, NOBUO</au><au>MIWA, MASANORI</au><au>TSUJII, SHINJI</au><au>AIDA, SATOSHI</au><au>KOHCHI, YASUNORI</au><au>KOHCHI, MASAMI</au><au>MIZUGUCHI, EISAKU</au><au>ISSHIKI, YOSHIAKI</au><au>IIKURA, HITOSHI</au><au>MURATA, TAKESHI</au><au>ASO, KOSUKE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>5-SUBSTITUTED-2-PHENYLAMINO-BENZAMIDE AS MEK INHIBITOR</title><date>2009-04-30</date><risdate>2009</risdate><abstract>5-SUBSTITUTED-2-PHENYLAMINOBENZAMIDES AS MEK INHIBITORS An objective of the present invention is to provide compounds that exhibit strong MEK-inhibiting activity and are stable in vivo and soluble in water, which can be used as preventive or therapeutic agents for proliferative diseases. The compounds of the present invention and pharmaceutically acceptable salts thereof are represented by the following formula (1): [where R1, R2, R3, R4, and X are the same as defined in the present patent application]. (no suitable figure)</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng
recordid cdi_epo_espacenet_SG151286A1
source esp@cenet
title 5-SUBSTITUTED-2-PHENYLAMINO-BENZAMIDE AS MEK INHIBITOR
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T11%3A42%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=MATSUBARA,%20YASUAKI&rft.date=2009-04-30&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ESG151286A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true