PLANT EXTRACTS ENRICHED WITH IPOLAMIIDE DERIVATIVES AS IMMUNOSUPPRESSANTS FOR TREATING IMMUNOLOGICAL DISORDERS

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 23 August 2018 (23.08.2018) WIP0 I PCT omit VIII °nolo VIII VIII IIII iflo (10) International Publication Number WO 2018/148816 A2 (51) International Patent Classification: CO7D 311/94 (2006.01) (21) International Application Number: PCT/BR2018/050037 (22) International Filing Date: 19 February 2018 (19.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: BR1020170033180 17 February 2017 (17.02.2017) BR (71) Applicant: ACHE LABORATORIOS FARMACEUTI- COS S.A. [BR/BR]; Rod. Presidente Dutra, s/n° - Km 222, Porto da Igreja, 07034-904 Guarulhos, SP (BR). (72) Inventors: GUIMARAES, Cristiano Ruch Werneck; Alameda dos Anapurus, 883, Apto 131 B, Moema, 04087-002 Sao Paulo, SP (BR). VITOR, Carlos Eduar- do; Rua Joao Ant6nio de Oliveira, 544, Apto 103 Turim, Mooca, 03111-010 Sao Paulo, SP (BR). PESSA, Lisandra Ravanelli; Travessa Vila Real, 8, Vila Mariana, 04118-095 Sao Paulo, SP (BR). REIS, Romulo Dragani; Praca Marisa Marques, 44, Apto 95, Vila Rosana, 07072-080 Guarulhos, SP (BR). MASCARELLO, Alessandra; Rua Santa Izabel, 451, 07023-022 Guarulhos, SP (BR). GAMA, Fernando Henrique De Souza; Rua da Penha, 55, 07197-130 Guarul- hos, SP (BR). (74) Agent: DANIEL ADVOGADOS; Av. Republica do Chile, 230, 3° andar, Centro, 20031-170 Rio De Janeiro, RJ (BR). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW,