MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS

MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for t...

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Hauptverfasser: ROBERTS, Tucker Curran, HIGUCHI, Robert I, BLENCH, Toby, CRAWFORD, James John, LY, Cuong Q, PARASELLI, Prasuna, HU, Huiyong, YU, Zhiyong, KOEHLER, Michael F. T, HANAN, Emily J, CHEN, Yongsheng, WINSHIP, Paul Colin Michael, SMITH, Peter Andrew, SCHWARZ, Jacob Bradley, MCCLEOD, Calum
Format: Patent
Sprache:eng
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Zusammenfassung:Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.