FORFARANDE FOR FRAMSTELLNING AV AZETIDINONETTIKSYRADERIVAT

FORFARANDE FOR FRAMSTELLNING AV AZETIDINONETTIKSYRADERIVAT

New heterocyclic acetic acid compounds of the general formula (I), wherein Y and Y form together a removable carbonyl protecting group, and R is a removable amido protecting group, are prepared in the way that a compound of the general formula (II), wherein R, Y and Y are as defined above, is activa...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: 8)K ZAUER, 1)K LEMPERT, 2)G DOLESCHALL, 3)J FETTER, 13)G HAJOS, 4)G HORNYAK, 5)P HUSZTHY, 12)L SZPORNY, 9)T GIZUR, 10)K HARSANYI, 6)J NYITRAI, 7)G SIMIG, 11)G FEKETE
Format: Patent
Sprache:swe
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:New heterocyclic acetic acid compounds of the general formula (I), wherein Y and Y form together a removable carbonyl protecting group, and R is a removable amido protecting group, are prepared in the way that a compound of the general formula (II), wherein R, Y and Y are as defined above, is activated on the carboxy group and then reacted with diazomethane, and the resulting new compound of the general formula (II), wherein R, Y and Y are as defined above, is subjected to diazoketone rearrangement in the presence of water. The new compounds according to the invention can be incorporated into pharmaceutical preparations and are valuable intermediates in the synthesis of thienamycin and thienamycin analogues.