SETT ATT FRAMSTELLA KONDENSERADE PYRIMIDINFORENINGAR, MED BROHUVUDSKVEVEATOM, SALTER, HYDRAT OCH ISOMERER DERAV
A process is disclosed for the preparation of compounds of the formula (I) wherein R1 and R2 are each hydrogen or lower alkyl; R3 is carboxy, lower alkoxycarbonyl, carbamoyl, carbamoyl substituted by one or two lower alkyl groups, or cyano; R4 is hydrogen, lower alkyl, phenyl, naphthyl, phenyl or na...
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| creator | 2)T BREINING 4)A HORVATH 1)I HERMECZ 5)J KOKOSI 3)L VASVARI |
| description | A process is disclosed for the preparation of compounds of the formula (I) wherein R1 and R2 are each hydrogen or lower alkyl; R3 is carboxy, lower alkoxycarbonyl, carbamoyl, carbamoyl substituted by one or two lower alkyl groups, or cyano; R4 is hydrogen, lower alkyl, phenyl, naphthyl, phenyl or naphthyl substituted by at least one fluoro, chloro, bromo, iodo, lower alkyl, lower alkoxy, hydroxy, carboxy, or phenyl, pyridyl or tetrazolyl; and R5 is hydrogen or lower alkyl; or a pharmaceutically acceptable salt, hydrate, stereoisomer, optically active isomer, geometric isomer, or tautomer thereof, which comprises the step of aminating a racemic or optically active compound of the formula (II) wherein X is halogen with a compound of the formula (III) or a pharmaceutically acceptable acid addition salt thereof. The compound of formula (II) possess antiallergic, especially antiasthma, activity. |
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The compound of formula (II) possess antiallergic, especially antiasthma, activity.</description><edition>4</edition><language>swe</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1985</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19851104&DB=EPODOC&CC=SE&NR=441748B$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76419</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19851104&DB=EPODOC&CC=SE&NR=441748B$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>2)T BREINING</creatorcontrib><creatorcontrib>4)A HORVATH</creatorcontrib><creatorcontrib>1)I HERMECZ</creatorcontrib><creatorcontrib>5)J KOKOSI</creatorcontrib><creatorcontrib>3)L VASVARI</creatorcontrib><title>SETT ATT FRAMSTELLA KONDENSERADE PYRIMIDINFORENINGAR, MED BROHUVUDSKVEVEATOM, SALTER, HYDRAT OCH ISOMERER DERAV</title><description>A process is disclosed for the preparation of compounds of the formula (I) wherein R1 and R2 are each hydrogen or lower alkyl; R3 is carboxy, lower alkoxycarbonyl, carbamoyl, carbamoyl substituted by one or two lower alkyl groups, or cyano; R4 is hydrogen, lower alkyl, phenyl, naphthyl, phenyl or naphthyl substituted by at least one fluoro, chloro, bromo, iodo, lower alkyl, lower alkoxy, hydroxy, carboxy, or phenyl, pyridyl or tetrazolyl; and R5 is hydrogen or lower alkyl; or a pharmaceutically acceptable salt, hydrate, stereoisomer, optically active isomer, geometric isomer, or tautomer thereof, which comprises the step of aminating a racemic or optically active compound of the formula (II) wherein X is halogen with a compound of the formula (III) or a pharmaceutically acceptable acid addition salt thereof. The compound of formula (II) possess antiallergic, especially antiasthma, activity.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1985</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFjLEKwjAURbs4iPoL8j6gDmJB19fm1QSbRF5eA51KkTiJLdT_xw7uDpcznMNdZ2MgEcBlNaMNQk2DcPNOkQvEqAjuHRtrlHG1Z3LGXZFzsKSgZK_b2KpwixQJxdscAjZCi9edYhTwlQYTvCUmBrX8xW22eg6vOe1-3GT7mqTShzSNfZqn4ZHe6dMHKorjubiUp7_BF6QXNtY</recordid><startdate>19851104</startdate><enddate>19851104</enddate><creator>2)T BREINING</creator><creator>4)A HORVATH</creator><creator>1)I HERMECZ</creator><creator>5)J KOKOSI</creator><creator>3)L VASVARI</creator><scope>EVB</scope></search><sort><creationdate>19851104</creationdate><title>SETT ATT FRAMSTELLA KONDENSERADE PYRIMIDINFORENINGAR, MED BROHUVUDSKVEVEATOM, SALTER, HYDRAT OCH ISOMERER DERAV</title><author>2)T BREINING ; 4)A HORVATH ; 1)I HERMECZ ; 5)J KOKOSI ; 3)L VASVARI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_SE441748B3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>swe</language><creationdate>1985</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>2)T BREINING</creatorcontrib><creatorcontrib>4)A HORVATH</creatorcontrib><creatorcontrib>1)I HERMECZ</creatorcontrib><creatorcontrib>5)J KOKOSI</creatorcontrib><creatorcontrib>3)L VASVARI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>2)T BREINING</au><au>4)A HORVATH</au><au>1)I HERMECZ</au><au>5)J KOKOSI</au><au>3)L VASVARI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SETT ATT FRAMSTELLA KONDENSERADE PYRIMIDINFORENINGAR, MED BROHUVUDSKVEVEATOM, SALTER, HYDRAT OCH ISOMERER DERAV</title><date>1985-11-04</date><risdate>1985</risdate><abstract>A process is disclosed for the preparation of compounds of the formula (I) wherein R1 and R2 are each hydrogen or lower alkyl; R3 is carboxy, lower alkoxycarbonyl, carbamoyl, carbamoyl substituted by one or two lower alkyl groups, or cyano; R4 is hydrogen, lower alkyl, phenyl, naphthyl, phenyl or naphthyl substituted by at least one fluoro, chloro, bromo, iodo, lower alkyl, lower alkoxy, hydroxy, carboxy, or phenyl, pyridyl or tetrazolyl; and R5 is hydrogen or lower alkyl; or a pharmaceutically acceptable salt, hydrate, stereoisomer, optically active isomer, geometric isomer, or tautomer thereof, which comprises the step of aminating a racemic or optically active compound of the formula (II) wherein X is halogen with a compound of the formula (III) or a pharmaceutically acceptable acid addition salt thereof. The compound of formula (II) possess antiallergic, especially antiasthma, activity.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | SETT ATT FRAMSTELLA KONDENSERADE PYRIMIDINFORENINGAR, MED BROHUVUDSKVEVEATOM, SALTER, HYDRAT OCH ISOMERER DERAV |
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