SE374541

(A) Separation of the cis and trans isomers of (I). R1,2 = lower alkyl; or NR1R2 = heterocyclyl, R3 = lower alkyl. (B) Conversion of the cis isomer into a mixt. of cis and trans. As analgesics free from undesirable secondary effects, espec. the trans isomer. A soln. of the mixed isomers in aq. HCl,...

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1. Verfasser:	SATZINGER G
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	SATZINGER G
description	(A) Separation of the cis and trans isomers of (I). R1,2 = lower alkyl; or NR1R2 = heterocyclyl, R3 = lower alkyl. (B) Conversion of the cis isomer into a mixt. of cis and trans. As analgesics free from undesirable secondary effects, espec. the trans isomer. A soln. of the mixed isomers in aq. HCl, at pH 2.5-3.5, is treated with 15-40% aq. ZnCl2 to ppt. a Zn complex of the cis isomer; this is separated and treated with conc. NH4OH-CHCl3 to recover the cis-base, whilst the trans-base is obtained from the soln. by basifn. to pH 8.5-9.5 and solvent extn. The cis isomer is converted into a cis-trans mixt. by heating with dicyclo-hexylamine, hydroquinone or alpha-naphthylamine at 150-160 deg.C, under N2, for ca. 3 hrs.
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HCl, at pH 2.5-3.5, is treated with 15-40% aq. ZnCl2 to ppt. a Zn complex of the cis isomer; this is separated and treated with conc. NH4OH-CHCl3 to recover the cis-base, whilst the trans-base is obtained from the soln. by basifn. to pH 8.5-9.5 and solvent extn. 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subjects	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	SE374541
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