SE323084

SE323084

Chromane compounds of formula where R1 is a hydrogen or halogen atom and R2 is a hydrogen atom or an acyl group, are obtained by cyclizing 2 - [(3R, 7R, 11R) - 3,7, 11,15-tetramethyl - 3 - hydroxy - hexadacyl] - trimethyl-p-benzoquinone in the presence of an acidic cyclization agent. The reaction m...

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Hauptverfasser: RUEEGG R, SCHUDEL P, MAYER H
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator RUEEGG R
SCHUDEL P
MAYER H
description Chromane compounds of formula where R1 is a hydrogen or halogen atom and R2 is a hydrogen atom or an acyl group, are obtained by cyclizing 2 - [(3R, 7R, 11R) - 3,7, 11,15-tetramethyl - 3 - hydroxy - hexadacyl] - trimethyl-p-benzoquinone in the presence of an acidic cyclization agent. The reaction may be carried out at 0 DEG to 40 DEG C. The acidic cyclization agent may be a mineral acid, e.g. sulphuric acid or phosphoric acid (preferably used with a solvent, e.g. methanol, ethanol or iso-propanol) or an alkanoic acid halide, e.g. acetyl chloride or propionyl chloride (used without a solvent). When a mineral acid is used [2R, 41R, 81R]-alpha-tocopherol is obtained directly; when an alkanoyl halide is used R1 is a halogen atom and R2 is an acyl group. Examples are given.
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The reaction may be carried out at 0 DEG to 40 DEG C. The acidic cyclization agent may be a mineral acid, e.g. sulphuric acid or phosphoric acid (preferably used with a solvent, e.g. methanol, ethanol or iso-propanol) or an alkanoic acid halide, e.g. acetyl chloride or propionyl chloride (used without a solvent). When a mineral acid is used [2R, 41R, 81R]-alpha-tocopherol is obtained directly; when an alkanoyl halide is used R1 is a halogen atom and R2 is an acyl group. 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The reaction may be carried out at 0 DEG to 40 DEG C. The acidic cyclization agent may be a mineral acid, e.g. sulphuric acid or phosphoric acid (preferably used with a solvent, e.g. methanol, ethanol or iso-propanol) or an alkanoic acid halide, e.g. acetyl chloride or propionyl chloride (used without a solvent). When a mineral acid is used [2R, 41R, 81R]-alpha-tocopherol is obtained directly; when an alkanoyl halide is used R1 is a halogen atom and R2 is an acyl group. Examples are given.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1970</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZOAIdjU2MjawMOFhYE1LzClO5YXS3Axybq4hzh66qQX58anFBYnJqXmpJfEw5U7GBBUAAF1EGY0</recordid><startdate>19700427</startdate><enddate>19700427</enddate><creator>RUEEGG R</creator><creator>SCHUDEL P</creator><creator>MAYER H</creator><scope>EVB</scope></search><sort><creationdate>19700427</creationdate><title>SE323084</title><author>RUEEGG R ; SCHUDEL P ; MAYER H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_SE323084B3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1970</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>RUEEGG R</creatorcontrib><creatorcontrib>SCHUDEL P</creatorcontrib><creatorcontrib>MAYER H</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>RUEEGG R</au><au>SCHUDEL P</au><au>MAYER H</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SE323084</title><date>1970-04-27</date><risdate>1970</risdate><abstract>Chromane compounds of formula &lt;FORM:1102199/C2/1&gt; where R1 is a hydrogen or halogen atom and R2 is a hydrogen atom or an acyl group, are obtained by cyclizing 2 - [(3R, 7R, 11R) - 3,7, 11,15-tetramethyl - 3 - hydroxy - hexadacyl] - trimethyl-p-benzoquinone in the presence of an acidic cyclization agent. The reaction may be carried out at 0 DEG to 40 DEG C. The acidic cyclization agent may be a mineral acid, e.g. sulphuric acid or phosphoric acid (preferably used with a solvent, e.g. methanol, ethanol or iso-propanol) or an alkanoic acid halide, e.g. acetyl chloride or propionyl chloride (used without a solvent). When a mineral acid is used [2R, 41R, 81R]-alpha-tocopherol is obtained directly; when an alkanoyl halide is used R1 is a halogen atom and R2 is an acyl group. Examples are given.</abstract><oa>free_for_read</oa></addata></record>
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title SE323084
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