METHOD OF STEREOSPECIFIC HYDROLYSIS OF PIPERIDINEDIONE DERIVATIVES, HYDROLYSIS PRODUCT AND METHOD OF PAROXETIN SYNTHESIS
FIELD: organic chemistry. SUBSTANCE: invention describes method of stereospecific hydrolysis of mixture of (+)- and (-)-isomers of compound of the formula (II)where R is C-alkyl using enzyme carboxylesterase (i) for preparing compound of the formula (IIIA)followed by separation of formed compound of...
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| creator | LOSON UILL'JAM PAUEHLL ALAN DEHVID KURZONS ALAN MARTIN KI |
| description | FIELD: organic chemistry. SUBSTANCE: invention describes method of stereospecific hydrolysis of mixture of (+)- and (-)-isomers of compound of the formula (II)where R is C-alkyl using enzyme carboxylesterase (i) for preparing compound of the formula (IIIA)followed by separation of formed compound of the formula (IIIA)from remained (-)-isomer of the formula (II), or (ii) for preparing compounds of the formula (IIIB)followed by separation of formed compound of the formula (IIIB)from remained (+)-isomer of the formula (II). EFFECT: improved method of synthesis.
Предложен способ стереоспецифического гидролиза смеси (+)- и (-)-изомеров соединения формулы (II), приведенной в описании, в которой R представляет собой C-алкил, с использованием фермента карбоксилэтеразы для получения соединения формулы (IIIA), приведенной в описании, с последующим отделением получающегося в результате соединения формулы (IIIA) от оставшегося (-)-изомера формулы (II), или для получения соединений формулы (IIIB) с последующим отделением образующегося в результате соединения формулы (IIIB) от остающегося (+)-изомера формулы (II). |
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Предложен способ стереоспецифического гидролиза смеси (+)- и (-)-изомеров соединения формулы (II), приведенной в описании, в которой R представляет собой C-алкил, с использованием фермента карбоксилэтеразы для получения соединения формулы (IIIA), приведенной в описании, с последующим отделением получающегося в результате соединения формулы (IIIA) от оставшегося (-)-изомера формулы (II), или для получения соединений формулы (IIIB) с последующим отделением образующегося в результате соединения формулы (IIIB) от остающегося (+)-изомера формулы (II).</description><language>eng ; rus</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>1996</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19960920&DB=EPODOC&CC=RU&NR=94046012A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19960920&DB=EPODOC&CC=RU&NR=94046012A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LOSON UILL'JAM PAUEHLL</creatorcontrib><creatorcontrib>ALAN DEHVID KURZONS</creatorcontrib><creatorcontrib>ALAN MARTIN KI</creatorcontrib><title>METHOD OF STEREOSPECIFIC HYDROLYSIS OF PIPERIDINEDIONE DERIVATIVES, HYDROLYSIS PRODUCT AND METHOD OF PAROXETIN SYNTHESIS</title><description>FIELD: organic chemistry. SUBSTANCE: invention describes method of stereospecific hydrolysis of mixture of (+)- and (-)-isomers of compound of the formula (II)where R is C-alkyl using enzyme carboxylesterase (i) for preparing compound of the formula (IIIA)followed by separation of formed compound of the formula (IIIA)from remained (-)-isomer of the formula (II), or (ii) for preparing compounds of the formula (IIIB)followed by separation of formed compound of the formula (IIIB)from remained (+)-isomer of the formula (II). EFFECT: improved method of synthesis.
Предложен способ стереоспецифического гидролиза смеси (+)- и (-)-изомеров соединения формулы (II), приведенной в описании, в которой R представляет собой C-алкил, с использованием фермента карбоксилэтеразы для получения соединения формулы (IIIA), приведенной в описании, с последующим отделением получающегося в результате соединения формулы (IIIA) от оставшегося (-)-изомера формулы (II), или для получения соединений формулы (IIIB) с последующим отделением образующегося в результате соединения формулы (IIIB) от остающегося (+)-изомера формулы (II).</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1996</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNzMEKwjAQBNBePIj6D_sBClWL4DFkt2RBk5Bsiz2VIvEkWqgHP98Kgh49DcM8Zpo9jyTGIbgSolAgFz1pLlmDaTC4QxM5vkfPngIjW0J2lgDHVivhmuLyl_rgsNICyiJ8r70K7kTCFmJjxdAo59nk0l2HtPjkLIOSRJtV6u9tGvrunG7p0YZqX-TFLl9v1PYP8gKfjjqM</recordid><startdate>19960920</startdate><enddate>19960920</enddate><creator>LOSON UILL'JAM PAUEHLL</creator><creator>ALAN DEHVID KURZONS</creator><creator>ALAN MARTIN KI</creator><scope>EVB</scope></search><sort><creationdate>19960920</creationdate><title>METHOD OF STEREOSPECIFIC HYDROLYSIS OF PIPERIDINEDIONE DERIVATIVES, HYDROLYSIS PRODUCT AND METHOD OF PAROXETIN SYNTHESIS</title><author>LOSON UILL'JAM PAUEHLL ; ALAN DEHVID KURZONS ; ALAN MARTIN KI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_RU94046012A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; rus</language><creationdate>1996</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>LOSON UILL'JAM PAUEHLL</creatorcontrib><creatorcontrib>ALAN DEHVID KURZONS</creatorcontrib><creatorcontrib>ALAN MARTIN KI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LOSON UILL'JAM PAUEHLL</au><au>ALAN DEHVID KURZONS</au><au>ALAN MARTIN KI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHOD OF STEREOSPECIFIC HYDROLYSIS OF PIPERIDINEDIONE DERIVATIVES, HYDROLYSIS PRODUCT AND METHOD OF PAROXETIN SYNTHESIS</title><date>1996-09-20</date><risdate>1996</risdate><abstract>FIELD: organic chemistry. SUBSTANCE: invention describes method of stereospecific hydrolysis of mixture of (+)- and (-)-isomers of compound of the formula (II)where R is C-alkyl using enzyme carboxylesterase (i) for preparing compound of the formula (IIIA)followed by separation of formed compound of the formula (IIIA)from remained (-)-isomer of the formula (II), or (ii) for preparing compounds of the formula (IIIB)followed by separation of formed compound of the formula (IIIB)from remained (+)-isomer of the formula (II). EFFECT: improved method of synthesis.
Предложен способ стереоспецифического гидролиза смеси (+)- и (-)-изомеров соединения формулы (II), приведенной в описании, в которой R представляет собой C-алкил, с использованием фермента карбоксилэтеразы для получения соединения формулы (IIIA), приведенной в описании, с последующим отделением получающегося в результате соединения формулы (IIIA) от оставшегося (-)-изомера формулы (II), или для получения соединений формулы (IIIB) с последующим отделением образующегося в результате соединения формулы (IIIB) от остающегося (+)-изомера формулы (II).</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY SPIRITS VINEGAR WINE |
| title | METHOD OF STEREOSPECIFIC HYDROLYSIS OF PIPERIDINEDIONE DERIVATIVES, HYDROLYSIS PRODUCT AND METHOD OF PAROXETIN SYNTHESIS |
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