CONJUGATES OF BINDER AND ACTIVE SUBSTANCE (ADC) HAVING ENZYMATICALLY CLEAVABLE GROUPS
FIELD: medicine.SUBSTANCE: invention relates to new conjugates of a binder and active substance (hereinafter - ADC) with improved properties, active metabolites of these ADC, as well as to a method for their preparation. In addition, the present invention relates to the use of these conjugates for t...
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| creator | BERNDT, Zandra ZOMMER, Anette DITTS, Liza MERSH, Shtefan KIRKHKHOFF, Dennis REBSTOK, Ann-Sofi SHTELTE-LYUDVIG, Beatriks GREVEN, Zimone LERKHEN, Khans-Georg MALERT, Kristof KHAMMER, Shtefani |
| description | FIELD: medicine.SUBSTANCE: invention relates to new conjugates of a binder and active substance (hereinafter - ADC) with improved properties, active metabolites of these ADC, as well as to a method for their preparation. In addition, the present invention relates to the use of these conjugates for the treatment and/or prevention of diseases, as well as to the use of these conjugates for the preparation of drugs for the treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic diseases, such as, for example, cancer.EFFECT: obtaining conjugates for the treatment of hyperproliferative an/or angiogenic diseases.31 cl, 2 dwg, 7 tbl, 11 ex
Изобретение относится к новым конъюгатам связующего и активного вещества (АDС) с улучшенными свойствами, активным метаболитам этих ADC, а также к способу их получения. Кроме того, настоящее изобретение относится к применению этих конъюгатов для лечения и/или профилактики заболеваний, а также к применению этих конъюгатов для приготовления лекарственных средств для лечения и/или профилактики заболеваний, в частности гиперпролиферативных и/или ангиогенных заболеваний, таких как, например, рак. 7 н. и 24 з.п. ф-лы, 2 ил., 7 табл., 11 пр. |
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Изобретение относится к новым конъюгатам связующего и активного вещества (АDС) с улучшенными свойствами, активным метаболитам этих ADC, а также к способу их получения. Кроме того, настоящее изобретение относится к применению этих конъюгатов для лечения и/или профилактики заболеваний, а также к применению этих конъюгатов для приготовления лекарственных средств для лечения и/или профилактики заболеваний, в частности гиперпролиферативных и/или ангиогенных заболеваний, таких как, например, рак. 7 н. и 24 з.п. ф-лы, 2 ил., 7 табл., 11 пр.</description><language>eng ; rus</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211207&DB=EPODOC&CC=RU&NR=2761390C2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25566,76549</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211207&DB=EPODOC&CC=RU&NR=2761390C2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BERNDT, Zandra</creatorcontrib><creatorcontrib>ZOMMER, Anette</creatorcontrib><creatorcontrib>DITTS, Liza</creatorcontrib><creatorcontrib>MERSH, Shtefan</creatorcontrib><creatorcontrib>KIRKHKHOFF, Dennis</creatorcontrib><creatorcontrib>REBSTOK, Ann-Sofi</creatorcontrib><creatorcontrib>SHTELTE-LYUDVIG, Beatriks</creatorcontrib><creatorcontrib>GREVEN, Zimone</creatorcontrib><creatorcontrib>LERKHEN, Khans-Georg</creatorcontrib><creatorcontrib>MALERT, Kristof</creatorcontrib><creatorcontrib>KHAMMER, Shtefani</creatorcontrib><title>CONJUGATES OF BINDER AND ACTIVE SUBSTANCE (ADC) HAVING ENZYMATICALLY CLEAVABLE GROUPS</title><description>FIELD: medicine.SUBSTANCE: invention relates to new conjugates of a binder and active substance (hereinafter - ADC) with improved properties, active metabolites of these ADC, as well as to a method for their preparation. In addition, the present invention relates to the use of these conjugates for the treatment and/or prevention of diseases, as well as to the use of these conjugates for the preparation of drugs for the treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic diseases, such as, for example, cancer.EFFECT: obtaining conjugates for the treatment of hyperproliferative an/or angiogenic diseases.31 cl, 2 dwg, 7 tbl, 11 ex
Изобретение относится к новым конъюгатам связующего и активного вещества (АDС) с улучшенными свойствами, активным метаболитам этих ADC, а также к способу их получения. Кроме того, настоящее изобретение относится к применению этих конъюгатов для лечения и/или профилактики заболеваний, а также к применению этих конъюгатов для приготовления лекарственных средств для лечения и/или профилактики заболеваний, в частности гиперпролиферативных и/или ангиогенных заболеваний, таких как, например, рак. 7 н. и 24 з.п. ф-лы, 2 ил., 7 табл., 11 пр.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyjsKwkAQANA0FqLeYUotBE1AsZzMTpKVdSL7g9iEIGslGoj3x8YDWL3mzbNArZxDjZ4dtBWUWhRbQFGA5HVkcKF0HoUY1qhoAw1GLTWw3LoLek1oTAdkGCOWhqG2bbi6ZTZ7DM8prX4uMqjYU7NN47tP0zjc0yt9ehvy42FfnHaUF3-UL8-9L9Q</recordid><startdate>20211207</startdate><enddate>20211207</enddate><creator>BERNDT, Zandra</creator><creator>ZOMMER, Anette</creator><creator>DITTS, Liza</creator><creator>MERSH, Shtefan</creator><creator>KIRKHKHOFF, Dennis</creator><creator>REBSTOK, Ann-Sofi</creator><creator>SHTELTE-LYUDVIG, Beatriks</creator><creator>GREVEN, Zimone</creator><creator>LERKHEN, Khans-Georg</creator><creator>MALERT, Kristof</creator><creator>KHAMMER, Shtefani</creator><scope>EVB</scope></search><sort><creationdate>20211207</creationdate><title>CONJUGATES OF BINDER AND ACTIVE SUBSTANCE (ADC) HAVING ENZYMATICALLY CLEAVABLE GROUPS</title><author>BERNDT, Zandra ; ZOMMER, Anette ; DITTS, Liza ; MERSH, Shtefan ; KIRKHKHOFF, Dennis ; REBSTOK, Ann-Sofi ; SHTELTE-LYUDVIG, Beatriks ; GREVEN, Zimone ; LERKHEN, Khans-Georg ; MALERT, Kristof ; KHAMMER, Shtefani</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_RU2761390C23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; rus</language><creationdate>2021</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>BERNDT, Zandra</creatorcontrib><creatorcontrib>ZOMMER, Anette</creatorcontrib><creatorcontrib>DITTS, Liza</creatorcontrib><creatorcontrib>MERSH, Shtefan</creatorcontrib><creatorcontrib>KIRKHKHOFF, Dennis</creatorcontrib><creatorcontrib>REBSTOK, Ann-Sofi</creatorcontrib><creatorcontrib>SHTELTE-LYUDVIG, Beatriks</creatorcontrib><creatorcontrib>GREVEN, Zimone</creatorcontrib><creatorcontrib>LERKHEN, Khans-Georg</creatorcontrib><creatorcontrib>MALERT, Kristof</creatorcontrib><creatorcontrib>KHAMMER, Shtefani</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BERNDT, Zandra</au><au>ZOMMER, Anette</au><au>DITTS, Liza</au><au>MERSH, Shtefan</au><au>KIRKHKHOFF, Dennis</au><au>REBSTOK, Ann-Sofi</au><au>SHTELTE-LYUDVIG, Beatriks</au><au>GREVEN, Zimone</au><au>LERKHEN, Khans-Georg</au><au>MALERT, Kristof</au><au>KHAMMER, Shtefani</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CONJUGATES OF BINDER AND ACTIVE SUBSTANCE (ADC) HAVING ENZYMATICALLY CLEAVABLE GROUPS</title><date>2021-12-07</date><risdate>2021</risdate><abstract>FIELD: medicine.SUBSTANCE: invention relates to new conjugates of a binder and active substance (hereinafter - ADC) with improved properties, active metabolites of these ADC, as well as to a method for their preparation. In addition, the present invention relates to the use of these conjugates for the treatment and/or prevention of diseases, as well as to the use of these conjugates for the preparation of drugs for the treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic diseases, such as, for example, cancer.EFFECT: obtaining conjugates for the treatment of hyperproliferative an/or angiogenic diseases.31 cl, 2 dwg, 7 tbl, 11 ex
Изобретение относится к новым конъюгатам связующего и активного вещества (АDС) с улучшенными свойствами, активным метаболитам этих ADC, а также к способу их получения. Кроме того, настоящее изобретение относится к применению этих конъюгатов для лечения и/или профилактики заболеваний, а также к применению этих конъюгатов для приготовления лекарственных средств для лечения и/или профилактики заболеваний, в частности гиперпролиферативных и/или ангиогенных заболеваний, таких как, например, рак. 7 н. и 24 з.п. ф-лы, 2 ил., 7 табл., 11 пр.</abstract><oa>free_for_read</oa></addata></record> |
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| title | CONJUGATES OF BINDER AND ACTIVE SUBSTANCE (ADC) HAVING ENZYMATICALLY CLEAVABLE GROUPS |
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