IMMUNOMODULATORY AND ANTIVIRAL AGENT BASED ON (2-((COUMARIN-7-YL)OXY)ETHYL) 3-HYDROXY-20(29)-LUPEN-28-OATE
FIELD: medicine.SUBSTANCE: invention refers to medicine and chemical-pharmaceutical industry and concerns a new immunomodulatory and antiviral agent based on a hybrid molecule of triterpenoid-coumarin derivatives, namely (2-((coumarin-7-yl)oxy)ethyl) 3-hydroxy 20(29)-lupen-28-oate.EFFECT: declared c...
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| creator | Shtro Anna Andreevna Abyshev Rashad Azad ogly Ivkin Dmitrij Yurevich Chekerda Elena Viktorovna Abyshev Azad Ziyad ogly Nguen Kong Bang Nguen Tkhi Khaj Ien Karavaeva Anna Vladimirovna |
| description | FIELD: medicine.SUBSTANCE: invention refers to medicine and chemical-pharmaceutical industry and concerns a new immunomodulatory and antiviral agent based on a hybrid molecule of triterpenoid-coumarin derivatives, namely (2-((coumarin-7-yl)oxy)ethyl) 3-hydroxy 20(29)-lupen-28-oate.EFFECT: declared compound has immunomodulatory properties, having an effect on activation of the humoral response, and expressed antiviral activity against influenza virus A/California/07/09 (H1N1)pdm09 in Balb/c mice in therapeutic and prophylactic mode of application in doses of 10 mg/kg, can be used in medical practice in treating and preventing viral infections.1 cl, 6 dwg, 2 tbl, 3 ex
Изобретение относится к медицине и химико-фармацевтической промышленности и касается нового иммуномодулирующего и противовирусного средства на основе гибридной молекулы производных тритерпеноида-кумарина, а именно (2-((кумарин-7-ил)окси)этил) 3-гидрокси 20(29)-лупен-28-оата. Заявляемое соединение обладает иммуномодулирующими свойствами, оказывая влияние на активацию гуморального ответа, и выраженной противовирусной активностью в отношении вируса гриппа A/California/07/09 (H1N1)pdm09 у мышей Balb/c при лечебно-профилактическом режиме применения в дозах 10 мг/кг, может найти применение в медицинской практике при лечении и профилактике вирусных инфекций. 6 ил., 2 табл., 3 пр. |
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Изобретение относится к медицине и химико-фармацевтической промышленности и касается нового иммуномодулирующего и противовирусного средства на основе гибридной молекулы производных тритерпеноида-кумарина, а именно (2-((кумарин-7-ил)окси)этил) 3-гидрокси 20(29)-лупен-28-оата. Заявляемое соединение обладает иммуномодулирующими свойствами, оказывая влияние на активацию гуморального ответа, и выраженной противовирусной активностью в отношении вируса гриппа A/California/07/09 (H1N1)pdm09 у мышей Balb/c при лечебно-профилактическом режиме применения в дозах 10 мг/кг, может найти применение в медицинской практике при лечении и профилактике вирусных инфекций. 6 ил., 2 табл., 3 пр.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>STEROIDS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNirEKwjAURbs4iPoPGdPhgabS1jE20QaSPImJmKkUiYOIFur_Ywc_wOFyDoc7zx7KmGDRoAiae3SRcCumeXVRjmvCj9J6sudnKQhaQhlQ2mAw3CkLFUSd4zXm0reTkQLaKNwUgK0p2-Wgw0laYDUg93KZze79c0yrHxcZOUjftJCGd5fGob-lV_p0LrCyLqtt0WyKPy5fpjk0wg</recordid><startdate>20190430</startdate><enddate>20190430</enddate><creator>Shtro Anna Andreevna</creator><creator>Abyshev Rashad Azad ogly</creator><creator>Ivkin Dmitrij Yurevich</creator><creator>Chekerda Elena Viktorovna</creator><creator>Abyshev Azad Ziyad ogly</creator><creator>Nguen Kong Bang</creator><creator>Nguen Tkhi Khaj Ien</creator><creator>Karavaeva Anna Vladimirovna</creator><scope>EVB</scope></search><sort><creationdate>20190430</creationdate><title>IMMUNOMODULATORY AND ANTIVIRAL AGENT BASED ON (2-((COUMARIN-7-YL)OXY)ETHYL) 3-HYDROXY-20(29)-LUPEN-28-OATE</title><author>Shtro Anna Andreevna ; Abyshev Rashad Azad ogly ; Ivkin Dmitrij Yurevich ; Chekerda Elena Viktorovna ; Abyshev Azad Ziyad ogly ; Nguen Kong Bang ; Nguen Tkhi Khaj Ien ; Karavaeva Anna Vladimirovna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_RU2686743C13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; rus</language><creationdate>2019</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>STEROIDS</topic><toplevel>online_resources</toplevel><creatorcontrib>Shtro Anna Andreevna</creatorcontrib><creatorcontrib>Abyshev Rashad Azad ogly</creatorcontrib><creatorcontrib>Ivkin Dmitrij Yurevich</creatorcontrib><creatorcontrib>Chekerda Elena Viktorovna</creatorcontrib><creatorcontrib>Abyshev Azad Ziyad ogly</creatorcontrib><creatorcontrib>Nguen Kong Bang</creatorcontrib><creatorcontrib>Nguen Tkhi Khaj Ien</creatorcontrib><creatorcontrib>Karavaeva Anna Vladimirovna</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Shtro Anna Andreevna</au><au>Abyshev Rashad Azad ogly</au><au>Ivkin Dmitrij Yurevich</au><au>Chekerda Elena Viktorovna</au><au>Abyshev Azad Ziyad ogly</au><au>Nguen Kong Bang</au><au>Nguen Tkhi Khaj Ien</au><au>Karavaeva Anna Vladimirovna</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>IMMUNOMODULATORY AND ANTIVIRAL AGENT BASED ON (2-((COUMARIN-7-YL)OXY)ETHYL) 3-HYDROXY-20(29)-LUPEN-28-OATE</title><date>2019-04-30</date><risdate>2019</risdate><abstract>FIELD: medicine.SUBSTANCE: invention refers to medicine and chemical-pharmaceutical industry and concerns a new immunomodulatory and antiviral agent based on a hybrid molecule of triterpenoid-coumarin derivatives, namely (2-((coumarin-7-yl)oxy)ethyl) 3-hydroxy 20(29)-lupen-28-oate.EFFECT: declared compound has immunomodulatory properties, having an effect on activation of the humoral response, and expressed antiviral activity against influenza virus A/California/07/09 (H1N1)pdm09 in Balb/c mice in therapeutic and prophylactic mode of application in doses of 10 mg/kg, can be used in medical practice in treating and preventing viral infections.1 cl, 6 dwg, 2 tbl, 3 ex
Изобретение относится к медицине и химико-фармацевтической промышленности и касается нового иммуномодулирующего и противовирусного средства на основе гибридной молекулы производных тритерпеноида-кумарина, а именно (2-((кумарин-7-ил)окси)этил) 3-гидрокси 20(29)-лупен-28-оата. Заявляемое соединение обладает иммуномодулирующими свойствами, оказывая влияние на активацию гуморального ответа, и выраженной противовирусной активностью в отношении вируса гриппа A/California/07/09 (H1N1)pdm09 у мышей Balb/c при лечебно-профилактическом режиме применения в дозах 10 мг/кг, может найти применение в медицинской практике при лечении и профилактике вирусных инфекций. 6 ил., 2 табл., 3 пр.</abstract><oa>free_for_read</oa></addata></record> |
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| title | IMMUNOMODULATORY AND ANTIVIRAL AGENT BASED ON (2-((COUMARIN-7-YL)OXY)ETHYL) 3-HYDROXY-20(29)-LUPEN-28-OATE |
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