N-(3-(5-(4-CHLOROPHENYL)-1N-PYRAZOLO[3,4-B]PYRIDINE-3-CARBONYL)-2,4-DIFLUOROPHENYL)PROPANE-1-SULPHONAMIDE CRYSTALLINE FORM, ACTIVE COMPONENT, PHARMACEUTICAL COMPOSITION AND MEDICINE
FIELD: chemistry.SUBSTANCE: invention relates to the field of organic chemistry, namely to N-(3-(5-(4-chlorophenyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propan-1-sulfonamide of formula 1 or its pharmaceutically acceptable salt. Invention also relates to a new crystalline form, a...
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| creator | Ivanenkov Yan Andreevich Chuprov-Netochin Roman Nikolaevich Leonov Sergej Viktorovich |
| description | FIELD: chemistry.SUBSTANCE: invention relates to the field of organic chemistry, namely to N-(3-(5-(4-chlorophenyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propan-1-sulfonamide of formula 1 or its pharmaceutically acceptable salt. Invention also relates to a new crystalline form, an active component, a pharmaceutical composition and a drug based on compound 1.1.EFFECT: new compound is obtained for the prevention or treatment of proliferative diseases, characterized by BRAF kinase mutation.10 cl, 4 dwg, 5 tbl, 10 ex
Изобретение относится к области органической химии, а именно к N-(3-(5-(4-хлорофенил)-1Н-пиразоло[3,4-b]пиридин-3-карбонил)-2,4-дифторофенил)пропан-1-сульфонамиду формулы 1 или его фармацевтически приемлемой соли. Также изобретение относится к новой кристаллической форме, активному компоненту, фармацевтической композиции и лекарственному средству на основе соединения 1. Технический результат: получено новое соединение, используемое для профилактики или лечения пролиферативного заболевания, характеризующегося мутацией BRAF киназы. 6 н. и 4 з.п. ф-лы, 4 ил., 5 табл., 10 пр. |
| format | Patent |
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Изобретение относится к области органической химии, а именно к N-(3-(5-(4-хлорофенил)-1Н-пиразоло[3,4-b]пиридин-3-карбонил)-2,4-дифторофенил)пропан-1-сульфонамиду формулы 1 или его фармацевтически приемлемой соли. Также изобретение относится к новой кристаллической форме, активному компоненту, фармацевтической композиции и лекарственному средству на основе соединения 1. Технический результат: получено новое соединение, используемое для профилактики или лечения пролиферативного заболевания, характеризующегося мутацией BRAF киназы. 6 н. и 4 з.п. ф-лы, 4 ил., 5 табл., 10 пр.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjMFKAzEQhvfiQarvkOMKO4ft7lqv0yRLAslMyGaFbZFSJD0VLdRX8_0MKnj19M_wff9_W30S1B3UA9Q9SOM4cjCaFvcALUFYIu7Y8b5reti-lNcqSxo6kBi3_K2tC1J2dPNfNZQLi9bCNLtgmNBbpYWMy5TQubIgRo6-ESiTfS6AfWDSlBoRDEaPUs_JSnQ_ZLLJMgkkJbxWVpb-XXVzOp6v-f43V5UYdZIG8uX9kK-X42t-yx-HOK8fN0_9MMi2-4fyBSM_SfI</recordid><startdate>20190129</startdate><enddate>20190129</enddate><creator>Ivanenkov Yan Andreevich</creator><creator>Chuprov-Netochin Roman Nikolaevich</creator><creator>Leonov Sergej Viktorovich</creator><scope>EVB</scope></search><sort><creationdate>20190129</creationdate><title>N-(3-(5-(4-CHLOROPHENYL)-1N-PYRAZOLO[3,4-B]PYRIDINE-3-CARBONYL)-2,4-DIFLUOROPHENYL)PROPANE-1-SULPHONAMIDE CRYSTALLINE FORM, ACTIVE COMPONENT, PHARMACEUTICAL COMPOSITION AND MEDICINE</title><author>Ivanenkov Yan Andreevich ; Chuprov-Netochin Roman Nikolaevich ; Leonov Sergej Viktorovich</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_RU2678455C13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; rus</language><creationdate>2019</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>Ivanenkov Yan Andreevich</creatorcontrib><creatorcontrib>Chuprov-Netochin Roman Nikolaevich</creatorcontrib><creatorcontrib>Leonov Sergej Viktorovich</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Ivanenkov Yan Andreevich</au><au>Chuprov-Netochin Roman Nikolaevich</au><au>Leonov Sergej Viktorovich</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>N-(3-(5-(4-CHLOROPHENYL)-1N-PYRAZOLO[3,4-B]PYRIDINE-3-CARBONYL)-2,4-DIFLUOROPHENYL)PROPANE-1-SULPHONAMIDE CRYSTALLINE FORM, ACTIVE COMPONENT, PHARMACEUTICAL COMPOSITION AND MEDICINE</title><date>2019-01-29</date><risdate>2019</risdate><abstract>FIELD: chemistry.SUBSTANCE: invention relates to the field of organic chemistry, namely to N-(3-(5-(4-chlorophenyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propan-1-sulfonamide of formula 1 or its pharmaceutically acceptable salt. Invention also relates to a new crystalline form, an active component, a pharmaceutical composition and a drug based on compound 1.1.EFFECT: new compound is obtained for the prevention or treatment of proliferative diseases, characterized by BRAF kinase mutation.10 cl, 4 dwg, 5 tbl, 10 ex
Изобретение относится к области органической химии, а именно к N-(3-(5-(4-хлорофенил)-1Н-пиразоло[3,4-b]пиридин-3-карбонил)-2,4-дифторофенил)пропан-1-сульфонамиду формулы 1 или его фармацевтически приемлемой соли. Также изобретение относится к новой кристаллической форме, активному компоненту, фармацевтической композиции и лекарственному средству на основе соединения 1. Технический результат: получено новое соединение, используемое для профилактики или лечения пролиферативного заболевания, характеризующегося мутацией BRAF киназы. 6 н. и 4 з.п. ф-лы, 4 ил., 5 табл., 10 пр.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | N-(3-(5-(4-CHLOROPHENYL)-1N-PYRAZOLO[3,4-B]PYRIDINE-3-CARBONYL)-2,4-DIFLUOROPHENYL)PROPANE-1-SULPHONAMIDE CRYSTALLINE FORM, ACTIVE COMPONENT, PHARMACEUTICAL COMPOSITION AND MEDICINE |
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