PROLACTIN RECEPTOR BINDING PROTEINS AND THEIR USE
FIELD: chemistry.SUBSTANCE: present invention relates to immunology. Antibody capable of binding prolactin receptor (PRLR) is proposed. Nucleic acid encoding it, an expression vector and a host cell for producing said antibody are also described. In addition, a pharmaceutical composition comprising...
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| creator | VAN Tszei KHSIEKH Chung-Ming DIDZHAMMARINO Enriko L TAKUR Archana CHZHAN Tsyan KHATCHINS Charlz V ANDERSON Mark CHAO Debra REJLLI Edvard B LONGENEKER Kenton L DZHADZH Rassell A EGAN Devid A |
| description | FIELD: chemistry.SUBSTANCE: present invention relates to immunology. Antibody capable of binding prolactin receptor (PRLR) is proposed. Nucleic acid encoding it, an expression vector and a host cell for producing said antibody are also described. In addition, a pharmaceutical composition comprising said antibody and an antibody-drug conjugate are considered.EFFECT: antibody of the present invention is useful for detecting PRLR and for inhibiting PRLR activity in a human suffering from a disorder in which PRLR activity is detrimental.11 cl, 11 dwg, 26 tbl, 10 ex
Настоящее изобретение относится к иммунологии. Предложено антитело, способное связывать рецептор пролактина (PRLR). Также описаны кодирующая его нуклеиновая кислота, экспрессионный вектор и клетка-хозяин для получения указанного антитела. Кроме того, рассмотрены фармацевтическая композиция, содержащая указанное антитело, и конъюгат антитела с лекарственным средством. Антитело по настоящему изобретению пригодно для обнаружения PRLR и для ингибирования активности PRLR у человека, страдающего нарушением, при котором активность PRLR является вредоносной. 6 н. и 5 з.п. ф-лы, 11 ил., 26 табл., 10 пр. |
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Настоящее изобретение относится к иммунологии. Предложено антитело, способное связывать рецептор пролактина (PRLR). Также описаны кодирующая его нуклеиновая кислота, экспрессионный вектор и клетка-хозяин для получения указанного антитела. Кроме того, рассмотрены фармацевтическая композиция, содержащая указанное антитело, и конъюгат антитела с лекарственным средством. Антитело по настоящему изобретению пригодно для обнаружения PRLR и для ингибирования активности PRLR у человека, страдающего нарушением, при котором активность PRLR является вредоносной. 6 н. и 5 з.п. ф-лы, 11 ил., 26 табл., 10 пр.</description><language>eng ; rus</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180817&DB=EPODOC&CC=RU&NR=2664463C2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180817&DB=EPODOC&CC=RU&NR=2664463C2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>VAN Tszei</creatorcontrib><creatorcontrib>KHSIEKH Chung-Ming</creatorcontrib><creatorcontrib>DIDZHAMMARINO Enriko L</creatorcontrib><creatorcontrib>TAKUR Archana</creatorcontrib><creatorcontrib>CHZHAN Tsyan</creatorcontrib><creatorcontrib>KHATCHINS Charlz V</creatorcontrib><creatorcontrib>ANDERSON Mark</creatorcontrib><creatorcontrib>CHAO Debra</creatorcontrib><creatorcontrib>REJLLI Edvard B</creatorcontrib><creatorcontrib>LONGENEKER Kenton L</creatorcontrib><creatorcontrib>DZHADZH Rassell A</creatorcontrib><creatorcontrib>EGAN Devid A</creatorcontrib><title>PROLACTIN RECEPTOR BINDING PROTEINS AND THEIR USE</title><description>FIELD: chemistry.SUBSTANCE: present invention relates to immunology. Antibody capable of binding prolactin receptor (PRLR) is proposed. Nucleic acid encoding it, an expression vector and a host cell for producing said antibody are also described. In addition, a pharmaceutical composition comprising said antibody and an antibody-drug conjugate are considered.EFFECT: antibody of the present invention is useful for detecting PRLR and for inhibiting PRLR activity in a human suffering from a disorder in which PRLR activity is detrimental.11 cl, 11 dwg, 26 tbl, 10 ex
Настоящее изобретение относится к иммунологии. Предложено антитело, способное связывать рецептор пролактина (PRLR). Также описаны кодирующая его нуклеиновая кислота, экспрессионный вектор и клетка-хозяин для получения указанного антитела. Кроме того, рассмотрены фармацевтическая композиция, содержащая указанное антитело, и конъюгат антитела с лекарственным средством. Антитело по настоящему изобретению пригодно для обнаружения PRLR и для ингибирования активности PRLR у человека, страдающего нарушением, при котором активность PRLR является вредоносной. 6 н. и 5 з.п. ф-лы, 11 ил., 26 табл., 10 пр.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDAMCPL3cXQO8fRTCHJ1dg0I8Q9ScPL0c_H0c1cASoW4evoFKzj6uSiEeLh6BimEBrvyMLCmJeYUp_JCaW4GBTfXEGcP3dSC_PjU4oLE5NS81JL4oFAjMzMTEzNjZyNjIpQAABc1JmM</recordid><startdate>20180817</startdate><enddate>20180817</enddate><creator>VAN Tszei</creator><creator>KHSIEKH Chung-Ming</creator><creator>DIDZHAMMARINO Enriko L</creator><creator>TAKUR Archana</creator><creator>CHZHAN Tsyan</creator><creator>KHATCHINS Charlz V</creator><creator>ANDERSON Mark</creator><creator>CHAO Debra</creator><creator>REJLLI Edvard B</creator><creator>LONGENEKER Kenton L</creator><creator>DZHADZH Rassell A</creator><creator>EGAN Devid A</creator><scope>EVB</scope></search><sort><creationdate>20180817</creationdate><title>PROLACTIN RECEPTOR BINDING PROTEINS AND THEIR USE</title><author>VAN Tszei ; KHSIEKH Chung-Ming ; DIDZHAMMARINO Enriko L ; TAKUR Archana ; CHZHAN Tsyan ; KHATCHINS Charlz V ; ANDERSON Mark ; CHAO Debra ; REJLLI Edvard B ; LONGENEKER Kenton L ; DZHADZH Rassell A ; EGAN Devid A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_RU2664463C23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; rus</language><creationdate>2018</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>VAN Tszei</creatorcontrib><creatorcontrib>KHSIEKH Chung-Ming</creatorcontrib><creatorcontrib>DIDZHAMMARINO Enriko L</creatorcontrib><creatorcontrib>TAKUR Archana</creatorcontrib><creatorcontrib>CHZHAN Tsyan</creatorcontrib><creatorcontrib>KHATCHINS Charlz V</creatorcontrib><creatorcontrib>ANDERSON Mark</creatorcontrib><creatorcontrib>CHAO Debra</creatorcontrib><creatorcontrib>REJLLI Edvard B</creatorcontrib><creatorcontrib>LONGENEKER Kenton L</creatorcontrib><creatorcontrib>DZHADZH Rassell A</creatorcontrib><creatorcontrib>EGAN Devid A</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>VAN Tszei</au><au>KHSIEKH Chung-Ming</au><au>DIDZHAMMARINO Enriko L</au><au>TAKUR Archana</au><au>CHZHAN Tsyan</au><au>KHATCHINS Charlz V</au><au>ANDERSON Mark</au><au>CHAO Debra</au><au>REJLLI Edvard B</au><au>LONGENEKER Kenton L</au><au>DZHADZH Rassell A</au><au>EGAN Devid A</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROLACTIN RECEPTOR BINDING PROTEINS AND THEIR USE</title><date>2018-08-17</date><risdate>2018</risdate><abstract>FIELD: chemistry.SUBSTANCE: present invention relates to immunology. Antibody capable of binding prolactin receptor (PRLR) is proposed. Nucleic acid encoding it, an expression vector and a host cell for producing said antibody are also described. In addition, a pharmaceutical composition comprising said antibody and an antibody-drug conjugate are considered.EFFECT: antibody of the present invention is useful for detecting PRLR and for inhibiting PRLR activity in a human suffering from a disorder in which PRLR activity is detrimental.11 cl, 11 dwg, 26 tbl, 10 ex
Настоящее изобретение относится к иммунологии. Предложено антитело, способное связывать рецептор пролактина (PRLR). Также описаны кодирующая его нуклеиновая кислота, экспрессионный вектор и клетка-хозяин для получения указанного антитела. Кроме того, рассмотрены фармацевтическая композиция, содержащая указанное антитело, и конъюгат антитела с лекарственным средством. Антитело по настоящему изобретению пригодно для обнаружения PRLR и для ингибирования активности PRLR у человека, страдающего нарушением, при котором активность PRLR является вредоносной. 6 н. и 5 з.п. ф-лы, 11 ил., 26 табл., 10 пр.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | PROLACTIN RECEPTOR BINDING PROTEINS AND THEIR USE |
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