CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS

FIELD: organic chemistry.SUBSTANCE: invention relates to organic chemistry, specifically to a compound of formula I or a pharmaceutically acceptable salt thereof (I),where A is selected from phenyl, isoindolinyl, quinolinyl, pyridinyl,,2,3-dihydro-1-indenyl, benzothazolyl and 1,2,3,4-tetrahydroisoquinolinyl; n is 0, 1, 2, or 3; m is 0, 1, 2, or 3; p is 2, 3, or 4; Ris selected from: halogen, oxo(=O), Calkyl(oxy)(carbonyl)Calkyl, CcycloalkylCalkyl, heteroaryl (carbonyl)Calkyl, where heteroaryl is a 5-6 membered ring containing 1-3 heteroatoms selected from nitrogen, nitrogen and oxygen, and nitrogen and sulphur, (C)heterocycloalkyl(carbonyl)Calkyl, where the 3-12 membered heterocycloalkyl contains 1-2 heteroatoms selected from nitrogen, oxygen, nitrogen, sulphur, nitrogen and oxygen, and oxygen and sulphur, Calkyl(oxy)(carbonyl)aminoCalkyl, heteroaryl(carbonyl)aminoCalkyl, where heteroaryl is a 5-6 membered ring containing 1-2 heteroatoms selected from nitrogen and oxygen, Calkylamino(carbonyl)Calkyl, heteroarylamino(carbonyl)Calkyl, wherein heteroaryl is a 5-membered ring containing 1-2 heteroatoms selected from nitrogen, Calkylsulfonyl, (C)cycloheteroalkylsulfonylCalkyl, where cycloheteroalkyl contains 1-2 heteroatoms selected from nitrogen and oxygen, Calkylsulfonimidoyl, CalkylthioCalkyl, -COH, -SONH, -SONH(Calkyl), -SON(Calkyl), -(Calkyl)OH, -Calkylalkoxy, cyano, and Chaloalkyl; and where two Rmay optionally bind to ring atoms to which they are attached to form a 3 to 6-membered ring; Ris selected from: halogen, Calkyl, (C)heterocycloalkyl, where heterocycloalkyl contains 1 nitrogen heteroatom, CcycloalkylCalkylamino, (Calkyl)amino, and hydroxy, where two Rmay optionally be bound to a ring atom to which each is attached to form a 3-6 membered saturated ring; and where Rand Reach is optionally substituted with 1, 2, 3 or 4 substituents R; Ris independently selected from: halogen, Calkyl, phenyl, Ccycloalkyl, piperidinyl, -CO(Calkyl), -COH, amino, (Calkyl)amino, hydroxy, (Calkyl) OH, CalkoxyCalkyl, (Calkyl) cyano, CalkylsulfinylCalkyl, -O(C=O)Calkyl, oxo and Chaloalkyl. Invention also relates to a pharmaceutical composition capable of inhibiting the activity of Janus kinases JAK1 and JAK2, and methods of treatment based on said compounds.EFFECT: technical result: novel compounds are obtained, that can be used in medicine for treatment of arthritis, asthma and obstructive airways diseases, autoimmune diseases or disorders and cancer.14 cl, 22 ex, 50 tbl И