1,5-NAPHTHRIDINE DERIVATIVES AND MELK INHIBITORS CONTAINING THEM

FIELD: pharmacology.SUBSTANCE: invention relates to a heterocyclic compound of the formula (I) or to a pharmaceutically acceptable salt thereof, wherein Xis selected from a direct bond or -NH; Qis selected from the group consisting of C-Ccycloalkyl, phenyl, pyridyl, pyrazolyl, pyrimidinyl, piperidyl, (C-Ccycloalkyl)-C-Calkyl and (3-10-membered non-aromatic heterocyclyl)-C-Calkyl; where Qis optionally substituted by one A; Xis selected from -CO- and -SO-; Ris selected from the group consisting of C-Calkyl and C-Ccycloalkyl, which are optionally substituted by one hydroxyl group; Ris selected from the group consisting of a halogen atom, C-Caryl, 5-10-membered heteroaryl and 3-10-membered non-aromatic heterocyclyl; wherein aryl, heteroaryl and heterocyclyl are optionally substituted by 1 to 3 substituents A; R, Rand Rrepresent a hydrogen atom; Ais selected from the group consisting of C-Calkyl, -NRR, -OR, 3-10-membered non-aromatic heterocyclyl and (CD)N-C-Calkyl; where alkyl and heterocyclyl are optionally substituted by one Aand where heterocyclyl is optionally substituted by one C-Calkyl; Ais independently selected from the group consisting of a halogen atom, cyano, C-Calkyl and -OR; Ris independently selected from the group consisting of a hydrogen atom, C-Calkyl and -COR; where alkyl is optionally substituted by one A; Ris selected from the group consisting of a hydrogen atom and C-Calkyl, which is optionally substituted by one A; or Ris selected from the group consisting of a hydrogen atom and C-Calkyl, where alkyl is optionally substituted by one or three A; Ris selected from the group consisting of C-Calkyl and 3-10-membered non-aromatic heterocyclyl; wherein alkyl and heterocyclyl are optionally substituted by one amino group; Aare independently selected from the group consisting of a halogen atom, -NRR, hydroxy and 3-10-membered non-aromatic heterocyclyl; where heterocyclyl is optionally substituted by one A; Rand Rare independently selected from the group consisting of a hydrogen atom and C-Calkyl, where alkyl is optionally substituted by one hydroxy group; Ais selected from the group consisting of a halogen atom, C-Calkyl and hydroxy; where the 5-10 membered heteroaryl is selected from the group consisting of pyridyl, pyrazolyl, pyrimidinyl, benzoimidazolyl and pyrrolopyridinyl; the 3 to 10-membered non-aromatic heterocyclyl is selected from the group consisting of piperidyl, piperazinyl, pyrrolidinyl and morpholinyl. The invention also relates to