PYRAZOLO [3,4-C] PYRIDINES AND METHODS OF APPLICATION THEREOF
FIELD: pharmacology.SUBSTANCE: subject of the invention is pyrazolo [3,4-c] pyridines of the formula I,including their stereoisomers, geometric isomers, tautomers and pharmaceutically acceptable salts, wherein Rand Rhave the values disclosed in the claims. These compounds are useful for inhibiting P...
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| creator | TSUI Viki Khsyao-Vej VEN Chzhaoyan DO Stiven LI Vendi VAN Syaotszin KHU Khuejyun KOLESNIKOV Aleksandr |
| description | FIELD: pharmacology.SUBSTANCE: subject of the invention is pyrazolo [3,4-c] pyridines of the formula I,including their stereoisomers, geometric isomers, tautomers and pharmaceutically acceptable salts, wherein Rand Rhave the values disclosed in the claims. These compounds are useful for inhibiting Pim-kinases and for treating disorders such as cancer, mediated by Pim-kinase. Methods for using compounds of formula I for in vitro, in situ and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells or related pathological conditions are disclosed.EFFECT: increased application effeciency.4 cl, 3 tbl, 328 ex
Объектом изобретения являются пиразоло[3,4-c]пиридины формулы I, включая их стереоизомеры, геометрические изомеры, таутомеры и фармацевтически приемлемые соли, где Rи Rимеют значения, раскрытые в формуле изобретения. Данные соединения полезны для ингибирования Pim-киназ и для лечения расстройств, таких как рак, опосредованных Pim-киназой. Раскрыты способы применения соединений формулы I для in vitro, in situ и in vivo диагностики, профилактики или лечения таких расстройств в клетках млекопитающих или связанных патологических состояний. 3 н. и 1 з.п. ф-лы, 3 табл., 328 пр. |
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Объектом изобретения являются пиразоло[3,4-c]пиридины формулы I, включая их стереоизомеры, геометрические изомеры, таутомеры и фармацевтически приемлемые соли, где Rи Rимеют значения, раскрытые в формуле изобретения. Данные соединения полезны для ингибирования Pim-киназ и для лечения расстройств, таких как рак, опосредованных Pim-киназой. Раскрыты способы применения соединений формулы I для in vitro, in situ и in vivo диагностики, профилактики или лечения таких расстройств в клетках млекопитающих или связанных патологических состояний. 3 н. и 1 з.п. ф-лы, 3 табл., 328 пр.</description><language>eng ; rus</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171215&DB=EPODOC&CC=RU&NR=2638116C2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171215&DB=EPODOC&CC=RU&NR=2638116C2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TSUI Viki Khsyao-Vej</creatorcontrib><creatorcontrib>VEN Chzhaoyan</creatorcontrib><creatorcontrib>DO Stiven</creatorcontrib><creatorcontrib>LI Vendi</creatorcontrib><creatorcontrib>VAN Syaotszin</creatorcontrib><creatorcontrib>KHU Khuejyun</creatorcontrib><creatorcontrib>KOLESNIKOV Aleksandr</creatorcontrib><title>PYRAZOLO [3,4-C] PYRIDINES AND METHODS OF APPLICATION THEREOF</title><description>FIELD: pharmacology.SUBSTANCE: subject of the invention is pyrazolo [3,4-c] pyridines of the formula I,including their stereoisomers, geometric isomers, tautomers and pharmaceutically acceptable salts, wherein Rand Rhave the values disclosed in the claims. These compounds are useful for inhibiting Pim-kinases and for treating disorders such as cancer, mediated by Pim-kinase. Methods for using compounds of formula I for in vitro, in situ and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells or related pathological conditions are disclosed.EFFECT: increased application effeciency.4 cl, 3 tbl, 328 ex
Объектом изобретения являются пиразоло[3,4-c]пиридины формулы I, включая их стереоизомеры, геометрические изомеры, таутомеры и фармацевтически приемлемые соли, где Rи Rимеют значения, раскрытые в формуле изобретения. Данные соединения полезны для ингибирования Pim-киназ и для лечения расстройств, таких как рак, опосредованных Pim-киназой. Раскрыты способы применения соединений формулы I для in vitro, in situ и in vivo диагностики, профилактики или лечения таких расстройств в клетках млекопитающих или связанных патологических состояний. 3 н. и 1 з.п. ф-лы, 3 табл., 328 пр.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLANiAxyjPL38VeINtYx0XWOVQAKeLp4-rkGKzj6uSj4uoZ4-LsEK_i7KTgGBPh4OjuGePr7KYR4uAa5-rvxMLCmJeYUp_JCaW4GBTfXEGcP3dSC_PjU4oLE5NS81JL4oFAjM2MLQ0MzZyNjIpQAANSSKXs</recordid><startdate>20171215</startdate><enddate>20171215</enddate><creator>TSUI Viki Khsyao-Vej</creator><creator>VEN Chzhaoyan</creator><creator>DO Stiven</creator><creator>LI Vendi</creator><creator>VAN Syaotszin</creator><creator>KHU Khuejyun</creator><creator>KOLESNIKOV Aleksandr</creator><scope>EVB</scope></search><sort><creationdate>20171215</creationdate><title>PYRAZOLO [3,4-C] PYRIDINES AND METHODS OF APPLICATION THEREOF</title><author>TSUI Viki Khsyao-Vej ; VEN Chzhaoyan ; DO Stiven ; LI Vendi ; VAN Syaotszin ; KHU Khuejyun ; KOLESNIKOV Aleksandr</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_RU2638116C23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; rus</language><creationdate>2017</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>TSUI Viki Khsyao-Vej</creatorcontrib><creatorcontrib>VEN Chzhaoyan</creatorcontrib><creatorcontrib>DO Stiven</creatorcontrib><creatorcontrib>LI Vendi</creatorcontrib><creatorcontrib>VAN Syaotszin</creatorcontrib><creatorcontrib>KHU Khuejyun</creatorcontrib><creatorcontrib>KOLESNIKOV Aleksandr</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>TSUI Viki Khsyao-Vej</au><au>VEN Chzhaoyan</au><au>DO Stiven</au><au>LI Vendi</au><au>VAN Syaotszin</au><au>KHU Khuejyun</au><au>KOLESNIKOV Aleksandr</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PYRAZOLO [3,4-C] PYRIDINES AND METHODS OF APPLICATION THEREOF</title><date>2017-12-15</date><risdate>2017</risdate><abstract>FIELD: pharmacology.SUBSTANCE: subject of the invention is pyrazolo [3,4-c] pyridines of the formula I,including their stereoisomers, geometric isomers, tautomers and pharmaceutically acceptable salts, wherein Rand Rhave the values disclosed in the claims. These compounds are useful for inhibiting Pim-kinases and for treating disorders such as cancer, mediated by Pim-kinase. Methods for using compounds of formula I for in vitro, in situ and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells or related pathological conditions are disclosed.EFFECT: increased application effeciency.4 cl, 3 tbl, 328 ex
Объектом изобретения являются пиразоло[3,4-c]пиридины формулы I, включая их стереоизомеры, геометрические изомеры, таутомеры и фармацевтически приемлемые соли, где Rи Rимеют значения, раскрытые в формуле изобретения. Данные соединения полезны для ингибирования Pim-киназ и для лечения расстройств, таких как рак, опосредованных Pim-киназой. Раскрыты способы применения соединений формулы I для in vitro, in situ и in vivo диагностики, профилактики или лечения таких расстройств в клетках млекопитающих или связанных патологических состояний. 3 н. и 1 з.п. ф-лы, 3 табл., 328 пр.</abstract><oa>free_for_read</oa></addata></record> |
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| title | PYRAZOLO [3,4-C] PYRIDINES AND METHODS OF APPLICATION THEREOF |
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