ANTIBODIES TO HUMAN CSF-1R AND USE THEREOF

FIELD: biochemistry.SUBSTANCE: invention relates to biochemistry. Antibody against human macrophage colony-stimulating factor 1 receptor (CSF-1R) is presented. Invention also relates to method of producing above antibody, pharmaceutical composition and use of above antibody.EFFECT: invention enables...

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Hauptverfasser: Aleksander FIDLER, Karola RIS, Klaus KALUTSA, Marlene TOMAS, Georg FERTIG, Shtefan ZEEBER
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creator Aleksander FIDLER
Karola RIS
Klaus KALUTSA
Marlene TOMAS
Georg FERTIG
Shtefan ZEEBER
description FIELD: biochemistry.SUBSTANCE: invention relates to biochemistry. Antibody against human macrophage colony-stimulating factor 1 receptor (CSF-1R) is presented. Invention also relates to method of producing above antibody, pharmaceutical composition and use of above antibody.EFFECT: invention enables inhibiting binding of CSF-1 with CSF-1R and can be used for treating cancer, bone loss, inflammatory diseases, as well as for preventing or treating metastases.12 cl, 1 dwg, 7 tbl, 8 ex Изобретение относится к области биохимии. Представлено антитело против рецептора 1 колониестимулирующего фактора макрофагов (CSF-1R) человека. Также изобретение относится к способу получения указанного антитела, фармацевтической композиции и применению указанного антитела. Изобретение позволяет ингибировать связывание CSF-1 с CSF-1R и может быть использовано для лечения рака, разрежения костей, воспалительных заболеваний, а также для предупреждения или лечения метастазов. 10 н. и 2 з.п. ф-лы, 1 ил., 7 табл., 8 пр.
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subjects BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
title ANTIBODIES TO HUMAN CSF-1R AND USE THEREOF
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