HIGH AFFINITY AND AGGREGATIONALLY STABLE ANTIBODIES BASED ON VL VARIABLE DOMAINS AND VHH DERIVATIVE
FIELD: medicine, pharmacy.SUBSTANCE: invention refers to biochemistry. A humanized IgG type monoclonal antibody that binds to human 17A interleukin is proposed. The antibody contains variable domains as a combination of VHH derivative with a light chain VL variable domain. The said VHH derivative co...
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| creator | Ulitin Andrej Borisovich Sofronova Ekaterina Vladimirovna Solovev Valerij Vladimirovich Chernovskaya Tatyana Veniaminovna Chernykh Yuliya Sergeevna Morozov Dmitrij Valentinovich Nemankin Timofej Aleksandrovich Ekimova Viktoriya Mikhajlovna Evdokimov Stanislav Rudolfovich Goncharova Olga Vladimirovna Ivanov Roman Alekseevich Ustyugov Yakov Yurevich Korzhavin Dmitrij Valerevich |
| description | FIELD: medicine, pharmacy.SUBSTANCE: invention refers to biochemistry. A humanized IgG type monoclonal antibody that binds to human 17A interleukin is proposed. The antibody contains variable domains as a combination of VHH derivative with a light chain VL variable domain. The said VHH derivative contains amino acid substitutions at positions 44 and 45 (according to Kabat numbering). The invention also refers to DNA encoding the antibody, expression vector, cell line and a method for production of the said antibody. Furthermore, a pharmaceutical composition for treatment of IL-17A-mediated disease or disorder, comprising the antibody is proposed.EFFECT: invention allows to obtain antibodies with high affinity and enhanced aggregation stability.15 cl, 17 dwg, 6 tbl, 19 ex
Изобретение относится к области биохимии. Предложено гуманизированное моноклональное антитело типа IgG, связывающееся с интерлейкином 17A человека. Антитело содержит вариабельные домены в виде комбинации производного VHH с вариабельным доменом легкой цепи V. Указанное производное VHH содержит замены аминокислот в позициях 44 и 45 (по нумерации по Kabat). Также изобретение относится к ДНК, кодирующей указанное антитело, экспрессионному вектору, клеточной линии и способу получения указанного антитела. Кроме того, предложена фармацевтическая композиция для лечения опосредуемого IL-17A заболевания или нарушения, содержащая указанное антитело. Изобретение позволяет получить антитела с повышенной аффинностью и улучшенной агрегационной стабильностью. 7 н. и 18 з.п. ф-лы, 17 ил., 6 табл., 19 пр. |
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Изобретение относится к области биохимии. Предложено гуманизированное моноклональное антитело типа IgG, связывающееся с интерлейкином 17A человека. Антитело содержит вариабельные домены в виде комбинации производного VHH с вариабельным доменом легкой цепи V. Указанное производное VHH содержит замены аминокислот в позициях 44 и 45 (по нумерации по Kabat). Также изобретение относится к ДНК, кодирующей указанное антитело, экспрессионному вектору, клеточной линии и способу получения указанного антитела. Кроме того, предложена фармацевтическая композиция для лечения опосредуемого IL-17A заболевания или нарушения, содержащая указанное антитело. Изобретение позволяет получить антитела с повышенной аффинностью и улучшенной агрегационной стабильностью. 7 н. и 18 з.п. ф-лы, 17 ил., 6 табл., 19 пр.</description><language>eng ; rus</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170202&DB=EPODOC&CC=RU&NR=2609627C2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170202&DB=EPODOC&CC=RU&NR=2609627C2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Ulitin Andrej Borisovich</creatorcontrib><creatorcontrib>Sofronova Ekaterina Vladimirovna</creatorcontrib><creatorcontrib>Solovev Valerij Vladimirovich</creatorcontrib><creatorcontrib>Chernovskaya Tatyana Veniaminovna</creatorcontrib><creatorcontrib>Chernykh Yuliya Sergeevna</creatorcontrib><creatorcontrib>Morozov Dmitrij Valentinovich</creatorcontrib><creatorcontrib>Nemankin Timofej Aleksandrovich</creatorcontrib><creatorcontrib>Ekimova Viktoriya Mikhajlovna</creatorcontrib><creatorcontrib>Evdokimov Stanislav Rudolfovich</creatorcontrib><creatorcontrib>Goncharova Olga Vladimirovna</creatorcontrib><creatorcontrib>Ivanov Roman Alekseevich</creatorcontrib><creatorcontrib>Ustyugov Yakov Yurevich</creatorcontrib><creatorcontrib>Korzhavin Dmitrij Valerevich</creatorcontrib><title>HIGH AFFINITY AND AGGREGATIONALLY STABLE ANTIBODIES BASED ON VL VARIABLE DOMAINS AND VHH DERIVATIVE</title><description>FIELD: medicine, pharmacy.SUBSTANCE: invention refers to biochemistry. A humanized IgG type monoclonal antibody that binds to human 17A interleukin is proposed. The antibody contains variable domains as a combination of VHH derivative with a light chain VL variable domain. The said VHH derivative contains amino acid substitutions at positions 44 and 45 (according to Kabat numbering). The invention also refers to DNA encoding the antibody, expression vector, cell line and a method for production of the said antibody. Furthermore, a pharmaceutical composition for treatment of IL-17A-mediated disease or disorder, comprising the antibody is proposed.EFFECT: invention allows to obtain antibodies with high affinity and enhanced aggregation stability.15 cl, 17 dwg, 6 tbl, 19 ex
Изобретение относится к области биохимии. Предложено гуманизированное моноклональное антитело типа IgG, связывающееся с интерлейкином 17A человека. Антитело содержит вариабельные домены в виде комбинации производного VHH с вариабельным доменом легкой цепи V. Указанное производное VHH содержит замены аминокислот в позициях 44 и 45 (по нумерации по Kabat). Также изобретение относится к ДНК, кодирующей указанное антитело, экспрессионному вектору, клеточной линии и способу получения указанного антитела. Кроме того, предложена фармацевтическая композиция для лечения опосредуемого IL-17A заболевания или нарушения, содержащая указанное антитело. Изобретение позволяет получить антитела с повышенной аффинностью и улучшенной агрегационной стабильностью. 7 н. и 18 з.п. ф-лы, 17 ил., 6 табл., 19 пр.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjEEKwjAQAHPxIOof9gOCRKh43DbbZCEmkMRAT6WUeBIt1P9jKT7A0xxmmK0YDWsD2LbsOHWATgFqHUhjYu_Q2g5iwtrSohLXXjFFqDGSAu8gW8gYePXK35BdXBfZGFAUOC-XTHuxeQzPuRx-3AloKTXmWKZ3X-ZpGMurfPpwl9XpWslLI89_JF99cDOb</recordid><startdate>20170202</startdate><enddate>20170202</enddate><creator>Ulitin Andrej Borisovich</creator><creator>Sofronova Ekaterina Vladimirovna</creator><creator>Solovev Valerij Vladimirovich</creator><creator>Chernovskaya Tatyana Veniaminovna</creator><creator>Chernykh Yuliya Sergeevna</creator><creator>Morozov Dmitrij Valentinovich</creator><creator>Nemankin Timofej Aleksandrovich</creator><creator>Ekimova Viktoriya Mikhajlovna</creator><creator>Evdokimov Stanislav Rudolfovich</creator><creator>Goncharova Olga Vladimirovna</creator><creator>Ivanov Roman Alekseevich</creator><creator>Ustyugov Yakov Yurevich</creator><creator>Korzhavin Dmitrij Valerevich</creator><scope>EVB</scope></search><sort><creationdate>20170202</creationdate><title>HIGH AFFINITY AND AGGREGATIONALLY STABLE ANTIBODIES BASED ON VL VARIABLE DOMAINS AND VHH DERIVATIVE</title><author>Ulitin Andrej Borisovich ; Sofronova Ekaterina Vladimirovna ; Solovev Valerij Vladimirovich ; Chernovskaya Tatyana Veniaminovna ; Chernykh Yuliya Sergeevna ; Morozov Dmitrij Valentinovich ; Nemankin Timofej Aleksandrovich ; Ekimova Viktoriya Mikhajlovna ; Evdokimov Stanislav Rudolfovich ; Goncharova Olga Vladimirovna ; Ivanov Roman Alekseevich ; Ustyugov Yakov Yurevich ; Korzhavin Dmitrij Valerevich</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_RU2609627C23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; rus</language><creationdate>2017</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>Ulitin Andrej Borisovich</creatorcontrib><creatorcontrib>Sofronova Ekaterina Vladimirovna</creatorcontrib><creatorcontrib>Solovev Valerij Vladimirovich</creatorcontrib><creatorcontrib>Chernovskaya Tatyana Veniaminovna</creatorcontrib><creatorcontrib>Chernykh Yuliya Sergeevna</creatorcontrib><creatorcontrib>Morozov Dmitrij Valentinovich</creatorcontrib><creatorcontrib>Nemankin Timofej Aleksandrovich</creatorcontrib><creatorcontrib>Ekimova Viktoriya Mikhajlovna</creatorcontrib><creatorcontrib>Evdokimov Stanislav Rudolfovich</creatorcontrib><creatorcontrib>Goncharova Olga Vladimirovna</creatorcontrib><creatorcontrib>Ivanov Roman Alekseevich</creatorcontrib><creatorcontrib>Ustyugov Yakov Yurevich</creatorcontrib><creatorcontrib>Korzhavin Dmitrij Valerevich</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Ulitin Andrej Borisovich</au><au>Sofronova Ekaterina Vladimirovna</au><au>Solovev Valerij Vladimirovich</au><au>Chernovskaya Tatyana Veniaminovna</au><au>Chernykh Yuliya Sergeevna</au><au>Morozov Dmitrij Valentinovich</au><au>Nemankin Timofej Aleksandrovich</au><au>Ekimova Viktoriya Mikhajlovna</au><au>Evdokimov Stanislav Rudolfovich</au><au>Goncharova Olga Vladimirovna</au><au>Ivanov Roman Alekseevich</au><au>Ustyugov Yakov Yurevich</au><au>Korzhavin Dmitrij Valerevich</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>HIGH AFFINITY AND AGGREGATIONALLY STABLE ANTIBODIES BASED ON VL VARIABLE DOMAINS AND VHH DERIVATIVE</title><date>2017-02-02</date><risdate>2017</risdate><abstract>FIELD: medicine, pharmacy.SUBSTANCE: invention refers to biochemistry. A humanized IgG type monoclonal antibody that binds to human 17A interleukin is proposed. The antibody contains variable domains as a combination of VHH derivative with a light chain VL variable domain. The said VHH derivative contains amino acid substitutions at positions 44 and 45 (according to Kabat numbering). The invention also refers to DNA encoding the antibody, expression vector, cell line and a method for production of the said antibody. Furthermore, a pharmaceutical composition for treatment of IL-17A-mediated disease or disorder, comprising the antibody is proposed.EFFECT: invention allows to obtain antibodies with high affinity and enhanced aggregation stability.15 cl, 17 dwg, 6 tbl, 19 ex
Изобретение относится к области биохимии. Предложено гуманизированное моноклональное антитело типа IgG, связывающееся с интерлейкином 17A человека. Антитело содержит вариабельные домены в виде комбинации производного VHH с вариабельным доменом легкой цепи V. Указанное производное VHH содержит замены аминокислот в позициях 44 и 45 (по нумерации по Kabat). Также изобретение относится к ДНК, кодирующей указанное антитело, экспрессионному вектору, клеточной линии и способу получения указанного антитела. Кроме того, предложена фармацевтическая композиция для лечения опосредуемого IL-17A заболевания или нарушения, содержащая указанное антитело. Изобретение позволяет получить антитела с повышенной аффинностью и улучшенной агрегационной стабильностью. 7 н. и 18 з.п. ф-лы, 17 ил., 6 табл., 19 пр.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | HIGH AFFINITY AND AGGREGATIONALLY STABLE ANTIBODIES BASED ON VL VARIABLE DOMAINS AND VHH DERIVATIVE |
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